Search Keyword:


Search option:


IID50395
 UniprotQ6DE08
ProteinAurora kinase B-A
Geneaurkb-a
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
361
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 76-361 Hetero dimer : IID50346Complex
 Evidence X-RAY 4b8l A Reference
       Region 4b8l A 78-86 disorder
       Region 4b8l A 87-235 order
       Region 4b8l A 236-251 disorder
       Region 4b8l A 252-351 order
       Region 4b8l A 352-361 disorder
 Evidence X-RAY 4b8m A Reference
       Region 4b8m A 78-86 disorder
       Region 4b8m A 87-357 order
       Region 4b8m A 358-361 disorder
 Evidence X-RAY 4b8m B Reference
       Region 4b8m B 78-357 order
       Region 4b8m B 358-361 disorder
 Evidence X-RAY 2bfx A Reference
       Region 2bfx A 78-85 disorder
       Region 2bfx A 86-355 order
       Region 2bfx A 356-361 disorder
 Evidence X-RAY 2bfx B Reference
       Region 2bfx B 78-101 order
       Region 2bfx B 102-104 disorder
       Region 2bfx B 105-356 order
       Region 2bfx B 357-361 disorder
 Evidence X-RAY 2bfy A Reference
       Region 2bfy A 78-85 disorder
       Region 2bfy A 86-356 order
       Region 2bfy A 357-361 disorder
 Evidence X-RAY 2bfy B Reference
       Region 2bfy B 78-356 order
       Region 2bfy B 357-361 disorder
 Evidence X-RAY 4c2v A Reference
       Region 4c2v A 76-86 disorder
       Region 4c2v A 87-357 order
       Region 4c2v A 358-360 disorder
 Evidence X-RAY 4c2v B Reference
       Region 4c2v B 76-356 order
       Region 4c2v B 357-360 disorder
 Evidence X-RAY 4c2w A Reference
       Region 4c2w A 78-87 disorder
       Region 4c2w A 88-356 order
 Evidence X-RAY 4c2w B Reference
       Region 4c2w B 78-355 order
       Region 4c2w B 356-356 disorder
 Evidence X-RAY 5eyk B Reference
       Region 5eyk B 81-356 order
 Evidence X-RAY 2vgp A Reference
       Region 2vgp A 78-87 disorder
       Region 2vgp A 88-102 order
       Region 2vgp A 103-105 disorder
       Region 2vgp A 106-356 order
       Region 2vgp A 357-361 disorder
 Evidence X-RAY 2vgp B Reference
       Region 2vgp B 78-355 order
       Region 2vgp B 356-361 disorder
 Evidence X-RAY 2vrx A Reference
       Region 2vrx A 77-86 disorder
       Region 2vrx A 87-355 order
       Region 2vrx A 356-361 disorder
 Evidence X-RAY 2vrx B Reference
       Region 2vrx B 77-100 order
       Region 2vrx B 101-104 disorder
       Region 2vrx B 105-355 order
       Region 2vrx B 356-361 disorder
 Evidence X-RAY 3ztx A Reference
       Region 3ztx A 78-86 disorder
       Region 3ztx A 87-356 order
       Region 3ztx A 357-361 disorder
 Evidence X-RAY 3ztx B Reference
       Region 3ztx B 78-99 order
       Region 3ztx B 100-104 disorder
       Region 3ztx B 105-355 order
       Region 3ztx B 356-361 disorder
Seq 78-361 Hetero tetramer : IID50346Complex
 Evidence X-RAY 2vgo B Reference
       Region 2vgo B 78-131 order
       Region 2vgo B 132-133 disorder
       Region 2vgo B 134-357 order
       Region 2vgo B 358-361 disorder
 Evidence X-RAY 2vgo A Reference
       Region 2vgo A 78-86 disorder
       Region 2vgo A 87-355 order
       Region 2vgo A 356-361 disorder
 Evidence X-RAY 5k3y B Reference
       Region 5k3y B 78-78 disorder
       Region 5k3y B 79-356 order
 Evidence X-RAY 5k3y A Reference
       Region 5k3y A 78-87 disorder
       Region 5k3y A 88-355 order
       Region 5k3y A 356-356 disorder
Seq 81-356 Hetero dimer : IID50346Complex
 Evidence X-RAY 5eyk A Reference
       Region 5eyk A 81-87 disorder
       Region 5eyk A 88-241 order
       Region 5eyk A 242-245 disorder
       Region 5eyk A 246-355 order
       Region 5eyk A 356-356 disorder
 
Prediction
NeProc
Disorder 1-84,352-361
Order 85-351
ProS 4-9
AlphaFold
Disorder 1-85,237-238,240-251,358-361
Order 86-236,239-239,252-357
Pfam Hmmer
PF00069 93-343 4.1e-78
Function
Function in SwissProt
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis.
Biological Process
Diagram with PDB data
aurkb-a/incenp-aMechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.