Search Keyword:


Search option:


IID50396
 UniprotQ6NUF4
ProteinTargeting protein for Xklp2-A
Genetpx2-a
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
716
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 270-350 Hetero dimer : IID50009Complex
 Evidence X-RAY 3knd B Reference
       Region 3knd B 270-282 disorder
       Region 3knd B 283-288 order
       Region 3knd B 289-321 disorder
       Region 3knd B 322-331 order
       Region 3knd B 332-350 disorder
Seq 477-716 Monomer :
 Evidence NMR 8cx6 A This region adopts a folded structure on microtubules. Reference
       Region 8cx6 A 477-716 order
       Region 8cx6 A 477-478 high_rmsd
       Region 8cx6 A 495-499 high_rmsd
       Region 8cx6 A 665-666 high_rmsd
       Region 8cx6 A 708-716 high_rmsd
Seqdisorder 477-716
 Evidence NMR Reference
       Region 477-716 disorder
SeqProS possible 283-288,322-331 nuclear localization signal (NLS) Hetero dimer : IID50009Complex
       Region 3knd B 283-288 order
       Region 3knd B 322-331 order
SeqProS verified 477-716 :
       Region 8cx6 A 477-716 order
       Region 477-716 disorder
Seqphosphorylation
    204-204 Phosphoserine; by plk1
 
Prediction
NeProc
Disorder 1-5,36-165,205-639,684-716
Order 6-35,166-204,640-683
ProS 1-5,36-36,57-61,225-236,249-255,271-282,301-306,332-349,364-383,401-406,449-463,477-496,501-513,524-546,555-582,591-612,625-639,684-716
AlphaFold
Disorder 1-27,37-96,98-177,211-224,231-231,233-233,235-251,259-291,316-331,333-333,341-345,380-380,383-392,401-401,416-425,435-435,438-438,447-447,455-455,457-487,491-491,496-502,505-505,531-532,546-546,613-628,712-716
Order 28-36,97-97,178-210,225-230,232-232,234-234,252-258,292-315,332-332,334-340,346-379,381-382,393-400,402-415,426-434,436-437,439-446,448-454,456-456,488-490,492-495,503-504,506-530,533-545,547-612,629-711
Pfam Hmmer
PF06886 631-687 6.7e-22
SEG 83-100 ,140-151 ,180-196 ,355-364 ,405-422 ,439-453 ,573-590 ,654-679
Function
Function in SwissProt
Spindle assembly factor. Required for normal assembly of mitotic spindles. Mediates the binding kif15 and aurka to spindle microtubules. Required for targeting kif15 to microtubule minus ends. Activates aurka by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity).
Biological Process
Diagram with PDB data
tpx2-a/KPNA2TPX2:importin-alpha complex