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IID50402
UniprotQ91XD6
ProteinVacuolar protein-sorting-associated protein 36
GeneVps36
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
386
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-139 Hetero dimer : P0CH28
 Evidence X-RAY 2dx5 A Reference
       Region 2dx5 A 1-9 disorder
       Region 2dx5 A 10-32 order
       Region 2dx5 A 33-34 disorder
       Region 2dx5 A 35-73 order
       Region 2dx5 A 74-80 disorder
       Region 2dx5 A 81-87 order
       Region 2dx5 A 88-100 disorder
       Region 2dx5 A 101-130 order
       Region 2dx5 A 131-139 disorder
 
Prediction
NeProc
Disorder 74-93,136-149,201-214
Order 1-73,94-135,150-200,215-386
ProS 80-93
AlphaFold
Disorder 76-76,134-160,163-163,167-167,170-170,203-203,206-212,215-215,218-219,223-223,225-239,279-279,386-386
Order 1-75,77-133,161-162,164-166,168-169,171-202,204-205,213-214,216-217,220-222,224-224,240-278,280-385
Pfam Hmmer
PF04132 126-384 8.8e-181
SEG 351-362
Function
Function in SwissProt
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.