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IID50403
 UniprotQ99176
ProteinProtein SRN2
GeneSRN2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
213
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 22-213 Hetero tetramer : IID50362Complex,IID50369Complex
 Evidence X-RAY 2p22 C Reference
       Region 2p22 C 22-40 order
       Region 2p22 C 41-46 disorder
       Region 2p22 C 47-213 order
Seq 130-213 Hetero trimer : IID50362Complex
 Evidence X-RAY 2caz C Reference
       Region 2caz C 130-138 disorder
       Region 2caz C 139-202 order
       Region 2caz C 203-213 disorder
 Evidence X-RAY 2caz F Reference
       Region 2caz F 130-149 disorder
       Region 2caz F 150-202 order
       Region 2caz F 203-213 disorder
 Evidence X-RAY 2f66 C Reference
       Region 2f66 C 132-141 disorder
       Region 2f66 C 142-206 order
       Region 2f66 C 207-213 disorder
 Evidence X-RAY 2f66 F Reference
       Region 2f66 F 132-144 disorder
       Region 2f66 F 145-207 order
       Region 2f66 F 208-213 disorder
 
Prediction
NeProc
Disorder 1-51
Order 52-213
ProS 1-30,51-51
AlphaFold
Disorder 1-22,29-47,211-213
Order 23-28,48-210
Pfam Hmmer
PF07200 56-202 9.5e-56
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole.
Biological Process
See also
Diagram with PDB data
STP22/VPS27Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment