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IID50407
 UniprotP21827
ProteinGuanine nucleotide exchange factor SRM1
GeneSRM1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
482
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-25 Hetero dimer : IID50009Complex
 Evidence X-RAY 4oih B Reference
       Region 4oih B 1-2 disorder
       Region 4oih B 3-5 order
       Region 4oih B 6-15 disorder
       Region 4oih B 16-25 order
Seq 1-482 Hetero dimer : IID50012Complex
 Evidence X-RAY 5t94 A Reference
       Region 5t94 A 1-1 disorder
       Region 5t94 A 2-6 order
       Region 5t94 A 7-15 disorder
       Region 5t94 A 16-122 order
       Region 5t94 A 123-140 disorder
       Region 5t94 A 141-482 order
Seq 2-482 Hetero dodecamer : IID50135Complex,IID50139Complex
 Evidence X-RAY 5hq2 K Reference
       Region 5hq2 K 2-22 disorder
       Region 5hq2 K 23-120 order
       Region 5hq2 K 121-144 disorder
       Region 5hq2 K 145-250 order
       Region 5hq2 K 251-257 disorder
       Region 5hq2 K 258-312 order
       Region 5hq2 K 313-316 disorder
       Region 5hq2 K 317-479 order
       Region 5hq2 K 480-482 disorder
Seq 27-482 Monomer :
 Evidence X-RAY 3of7 A Reference
       Region 3of7 A 27-121 order
       Region 3of7 A 122-142 disorder
       Region 3of7 A 143-482 order
SeqProS verified 2-6,16-24 Nuclear Localization Signal (NLS) Hetero dimer : IID50012Complex
       Region 5t94 A 2-6 order
       Region 5t94 A 16-122 order
       Region 5hq2 K 2-22 disorder
SeqProS verified 3-5,16-24 Nuclear Localization Signal (NLS) Hetero dimer : IID50009Complex
       Region 4oih B 3-5 order
       Region 4oih B 16-25 order
       Region 5hq2 K 2-22 disorder
Seqphosphorylation
    135-135 Phosphoserine
    136-136 Phosphoserine
 
Prediction
NeProc
Disorder 1-26,131-144,472-482
Order 27-130,145-471
ProS 1-14,139-144,472-482
AlphaFold
Disorder 1-25,125-140
Order 26-124,141-482
SEG 127-148 ,398-410
Function
Function in SwissProt
Guanine nucleotide exchange factor that promotes the exchange of GSP1/GSP2-bound GDP by GTP and controls RNA metabolism and transport. Involved in yeast pheromone response pathway and in mRNA metabolism. Involved in nuclear pore complex (NPC) assembly and required for mRNA and ribosome nuclear export. Binds chromatin and is involved NPC-mediated transcriptional control.