Search Keyword:


Search option:


IID50408
 UniprotQ8K1R7
ProteinSerine/threonine-protein kinase Nek9
GeneNek9
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
984
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 817-835 Hetero trimer : Q8TDX7
 Evidence X-RAY 5de2 D Reference
       Region 5de2 D 817-825 order
       Region 5de2 D 826-835 disorder
 Evidence X-RAY 5de2 C Reference
       Region 5de2 C 817-832 order
       Region 5de2 C 833-835 disorder
SeqProS predicted 817-832 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : Q8TDX7
       Region 5de2 C 817-832 order
       Region 5de2 D 817-825 order
Seqphosphorylation
    254-254 Phosphothreonine
    331-331 Phosphoserine
    333-333 Phosphothreonine
    741-741 Phosphoserine
    808-808 Phosphoserine
    839-839 Phosphoserine
    891-891 Phosphothreonine
    949-949 Phosphoserine
    983-983 Phosphoserine
    210-210 Phosphothreonine; by autocatalysis
    76-76 Phosphoserine
    52-52 Phosphotyrosine
    20-20 Phosphoserine
    16-16 Phosphoserine
    13-13 Phosphoserine
    2-2 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-48,318-408,686-696,736-815,822-888,939-984
Order 49-317,409-685,697-735,816-821,889-938
ProS 1-20,318-321,353-393,401-408,736-757,767-800,812-815,822-834,849-860,876-888,939-950,958-984
AlphaFold
Disorder 1-50,61-63,196-198,202-214,325-338,344-344,365-369,397-399,570-577,686-694,705-707,734-898,900-900,939-984
Order 51-60,64-195,199-201,215-324,339-343,345-364,370-396,400-569,578-685,695-704,708-733,899-899,901-938
Pfam Hmmer
PF00069 52-308 1.9e-66
PF00415 444-495 7e-05
PF00415 500-547 0.00063
SEG 19-49 ,296-313 ,638-649 ,752-767 ,889-900 ,910-927
Function
Function in SwissProt
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.