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IID50409
 UniprotQ9FN03
ProteinUltraviolet-B receptor UVR8
GeneUVR8
OrganismArabidopsis thaliana
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
440
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-405 Homo dimer :
 Evidence X-RAY 4d9s B Reference
       Region 4d9s B 1-13 disorder
       Region 4d9s B 14-382 order
       Region 4d9s B 383-384 disorder
       Region 4d9s B 385-395 order
       Region 4d9s B 396-405 disorder
 Evidence X-RAY 4d9s A Reference
       Region 4d9s A 1-13 disorder
       Region 4d9s A 14-396 order
       Region 4d9s A 397-405 disorder
 Evidence X-RAY 4dnw B Reference
       Region 4dnw B 12-385 order
 Evidence X-RAY 4dnw A Reference
       Region 4dnw A 12-12 disorder
       Region 4dnw A 13-381 order
       Region 4dnw A 382-385 disorder
Seq 10-381 Monomer :
 Evidence X-RAY 4dnu A Reference
       Region 4dnu A 10-381 order
 Evidence X-RAY 6xzl A Reference
       Region 6xzl A 12-381 order
Seq 12-381 Homo dimer :
 Evidence X-RAY 6xzm B Reference
       Region 6xzm B 12-14 disorder
       Region 6xzm B 15-381 order
 Evidence X-RAY 6xzm A Reference
       Region 6xzm A 12-14 disorder
       Region 6xzm A 15-381 order
 Evidence X-RAY 6xzn B Reference
       Region 6xzn B 12-14 disorder
       Region 6xzn B 15-101 order
       Region 6xzn B 102-107 disorder
       Region 6xzn B 108-381 order
 Evidence X-RAY 6xzn A Reference
       Region 6xzn A 12-14 disorder
       Region 6xzn A 15-381 order
Seq 12-381 Homo tetramer :
 Evidence X-RAY 4dnv D Reference
       Region 4dnv D 12-13 disorder
       Region 4dnv D 14-381 order
 Evidence X-RAY 4dnv C Reference
       Region 4dnv C 12-381 order
 Evidence X-RAY 4dnv B Reference
       Region 4dnv B 12-13 disorder
       Region 4dnv B 14-381 order
 Evidence X-RAY 4dnv A Reference
       Region 4dnv A 12-381 order
 Evidence X-RAY 6dd7 D Reference
       Region 6dd7 D 13-13 disorder
       Region 6dd7 D 14-381 order
 Evidence X-RAY 6dd7 C Reference
       Region 6dd7 C 13-13 disorder
       Region 6dd7 C 14-381 order
 Evidence X-RAY 6dd7 B Reference
       Region 6dd7 B 13-13 disorder
       Region 6dd7 B 14-381 order
 Evidence X-RAY 6dd7 A Reference
       Region 6dd7 A 13-13 disorder
       Region 6dd7 A 14-381 order
Seq 12-421 Hetero dimer : Q9FFA7
 Evidence X-RAY 8gqe B Reference
       Region 8gqe B 12-12 disorder
       Region 8gqe B 13-381 order
       Region 8gqe B 382-396 disorder
       Region 8gqe B 397-413 order
       Region 8gqe B 414-421 disorder
Seq 13-381 Homo tetramer :
 Evidence X-RAY 4naa A Reference
       Region 4naa A 13-381 order
 Evidence X-RAY 4naa B Reference
       Region 4naa B 13-381 order
 Evidence X-RAY 4naa C Reference
       Region 4naa C 13-381 order
 Evidence X-RAY 4naa D Reference
       Region 4naa D 13-381 order
 Evidence X-RAY 4nbm A Reference
       Region 4nbm A 13-381 order
 Evidence X-RAY 4nbm B Reference
       Region 4nbm B 13-381 order
 Evidence X-RAY 4nbm C Reference
       Region 4nbm C 13-381 order
 Evidence X-RAY 4nbm D Reference
       Region 4nbm D 13-381 order
 Evidence X-RAY 4nc4 A Reference
       Region 4nc4 A 13-381 order
 Evidence X-RAY 4nc4 B Reference
       Region 4nc4 B 13-381 order
 Evidence X-RAY 4nc4 C Reference
       Region 4nc4 C 13-381 order
 Evidence X-RAY 4nc4 D Reference
       Region 4nc4 D 13-381 order
Seqdisorder 397-423
 Evidence NMR¸CD Reference
       Region 397-423 disorder
Seq 406-413 Hetero dimer : P43254
 Evidence X-RAY 6qtq B Reference
       Region 6qtq B 406-411 order
       Region 6qtq B 412-413 disorder
 Evidence X-RAY 6qts B Reference
       Region 6qts B 406-412 order
       Region 6qts B 413-413 disorder
SeqProS verified 397-413 Hetero dimer : Q9FFA7
       Region 8gqe B 397-413 order
       Region 397-423 disorder
SeqProS verified 406-412 Hetero dimer : P43254
       Region 6qts B 406-412 order
       Region 6qtq B 406-411 order
       Region 397-423 disorder
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-12
Order 13-440
ProS 1-5
AlphaFold
Disorder 1-11,383-385,391-440
Order 12-382,386-390
Pfam Hmmer
PF00415 32-82 3.2e-06
PF00415 138-187 7.4e-09
PF00415 190-239 9.5e-07
PF00415 294-343 1.1e-09
Function
Function in SwissProt
UV-B specific signaling component that acts as a UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.