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IID90002
 UniprotP03070
ProteinLarge T antigen
GeneLarge T antigen
OrganismSimian virus 40
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
708
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 7-117 Hetero trimer : IID00017Complex
 Evidence X-RAY 1gh6 A Reference
       Region 1gh6 A 7-117 order
Seq 110-134 Hetero trimer : IID50009Complex
 Evidence X-RAY 1ejl A Reference
       Region 1ejl A 126-132 order
 Evidence X-RAY 1ejl B Reference
       Region 1ejl B 126-132 order
 Evidence X-RAY 1q1s A Reference
       Region 1q1s A 110-127 disorder
       Region 1q1s A 128-132 order
       Region 1q1s A 133-133 disorder
 Evidence X-RAY 1q1s B Reference
       Region 1q1s B 110-118 disorder
       Region 1q1s B 119-133 order
 Evidence X-RAY 1q1t A Reference
       Region 1q1t A 110-126 disorder
       Region 1q1t A 127-134 order
 Evidence X-RAY 1q1t B Reference
       Region 1q1t B 110-122 disorder
       Region 1q1t B 123-133 order
       Region 1q1t B 134-134 disorder
Seq 125-132 Hetero trimer : Q9C2K9
 Evidence X-RAY 4rxh A Reference
       Region 4rxh A 125-127 disorder
       Region 4rxh A 128-132 order
 Evidence X-RAY 4rxh C Reference
       Region 4rxh C 125-132 order
Seq 131-259 Homo tetramer :
 Evidence X-RAY 2itl A Reference
       Region 2itl A 131-133 disorder
       Region 2itl A 134-253 order
       Region 2itl A 254-259 disorder
 Evidence X-RAY 2itl B Reference
       Region 2itl B 131-134 disorder
       Region 2itl B 135-249 order
       Region 2itl B 250-259 disorder
Seq 131-259 Hetero dimer : IID00026Complex
 Evidence NMR 1z1d B Reference
       Region 1z1d B 131-259 order
Seq 131-259 Homo hexamer :
 Evidence X-RAY 2fuf A Reference
       Region 2fuf A 131-256 order
       Region 2fuf A 257-259 disorder
Seq 131-260 Monomer :
 Evidence NMR 1tbd A Reference
       Region 1tbd A 131-260 order
 Evidence NMR 2tbd A Reference
       Region 2tbd A 131-260 order
       Region 2tbd A 131-131 high_rmsd
       Region 2tbd A 258-260 high_rmsd
 Evidence X-RAY 3qk2 A Reference
       Region 3qk2 A 131-149 order
       Region 3qk2 A 150-150 disorder
       Region 3qk2 A 151-260 order
 Evidence X-RAY 3qn2 A Reference
       Region 3qn2 A 131-252 order
       Region 3qn2 A 253-253 disorder
       Region 3qn2 A 254-257 order
       Region 3qn2 A 258-260 disorder
Seq 131-260 Homo dimer :
 Evidence X-RAY 2if9 A Reference
       Region 2if9 A 131-260 order
 Evidence X-RAY 2if9 B Reference
       Region 2if9 B 131-260 order
 Evidence X-RAY 2ipr A Reference
       Region 2ipr A 131-131 disorder
       Region 2ipr A 132-258 order
       Region 2ipr A 259-259 disorder
 Evidence X-RAY 2ipr B Reference
       Region 2ipr B 131-133 disorder
       Region 2ipr B 134-257 order
       Region 2ipr B 258-259 disorder
 Evidence X-RAY 2itj A Reference
       Region 2itj A 131-131 disorder
       Region 2itj A 132-259 order
 Evidence X-RAY 2itj B Reference
       Region 2itj B 131-131 disorder
       Region 2itj B 132-214 order
       Region 2itj B 215-217 disorder
       Region 2itj B 218-252 order
       Region 2itj B 253-259 disorder
 Evidence X-RAY 4fgn A Reference
       Region 4fgn A 131-132 disorder
       Region 4fgn A 133-258 order
       Region 4fgn A 259-260 disorder
 Evidence X-RAY 4fgn B Reference
       Region 4fgn B 131-133 disorder
       Region 4fgn B 134-257 order
       Region 4fgn B 258-260 disorder
 Evidence X-RAY 5d9i A Reference
       Region 5d9i A 131-260 order
 Evidence X-RAY 5d9i B Reference
       Region 5d9i B 131-260 order
Seq 131-260 Homo dimer :
 Evidence X-RAY 2nl8 A Reference
       Region 2nl8 A 131-132 disorder
       Region 2nl8 A 133-249 order
       Region 2nl8 A 250-259 disorder
 Evidence X-RAY 2ntc A Reference
       Region 2ntc A 131-131 disorder
       Region 2ntc A 132-258 order
       Region 2ntc A 259-260 disorder
 Evidence X-RAY 2ntc B Reference
       Region 2ntc B 131-132 disorder
       Region 2ntc B 133-258 order
       Region 2ntc B 259-260 disorder
Seq 131-627 Homo tetramer :
 Evidence X-RAY 4gdf A Reference
       Region 4gdf A 131-627 order
 Evidence X-RAY 4gdf B Reference
       Region 4gdf B 131-627 order
 Evidence X-RAY 4gdf E Reference
       Region 4gdf E 131-627 order
 Evidence X-RAY 4gdf F Reference
       Region 4gdf F 131-627 order
Seq 251-627 Homo hexamer :
 Evidence X-RAY 1n25 A Reference
       Region 1n25 A 260-265 disorder
       Region 1n25 A 266-627 order
 Evidence X-RAY 1n25 B Reference
       Region 1n25 B 260-265 disorder
       Region 1n25 B 266-627 order
 Evidence X-RAY 1svl A Reference
       Region 1svl A 251-264 disorder
       Region 1svl A 265-627 order
 Evidence X-RAY 1svl B Reference
       Region 1svl B 251-265 disorder
       Region 1svl B 266-627 order
 Evidence X-RAY 1svl C Reference
       Region 1svl C 251-265 disorder
       Region 1svl C 266-627 order
 Evidence X-RAY 1svm A Reference
       Region 1svm A 251-265 disorder
       Region 1svm A 266-627 order
 Evidence X-RAY 1svm B Reference
       Region 1svm B 251-265 disorder
       Region 1svm B 266-627 order
 Evidence X-RAY 1svm C Reference
       Region 1svm C 251-264 disorder
       Region 1svm C 265-627 order
 Evidence X-RAY 1svm D Reference
       Region 1svm D 251-265 disorder
       Region 1svm D 266-627 order
 Evidence X-RAY 1svm E Reference
       Region 1svm E 251-265 disorder
       Region 1svm E 266-627 order
 Evidence X-RAY 1svm F Reference
       Region 1svm F 251-264 disorder
       Region 1svm F 265-627 order
 Evidence X-RAY 1svo A Reference
       Region 1svo A 251-265 disorder
       Region 1svo A 266-627 order
 Evidence X-RAY 1svo B Reference
       Region 1svo B 251-265 disorder
       Region 1svo B 266-627 order
Seq 260-627 Hetero dodecamer : IID00015Complex
 Evidence X-RAY 2h1l A Reference
       Region 2h1l A 260-265 disorder
       Region 2h1l A 266-627 order
 Evidence X-RAY 2h1l B Reference
       Region 2h1l B 260-265 disorder
       Region 2h1l B 266-627 order
 Evidence X-RAY 2h1l C Reference
       Region 2h1l C 260-264 disorder
       Region 2h1l C 265-627 order
 Evidence X-RAY 2h1l D Reference
       Region 2h1l D 260-265 disorder
       Region 2h1l D 266-627 order
 Evidence X-RAY 2h1l E Reference
       Region 2h1l E 260-265 disorder
       Region 2h1l E 266-627 order
 Evidence X-RAY 2h1l F Reference
       Region 2h1l F 260-264 disorder
       Region 2h1l F 265-627 order
 Evidence X-RAY 2h1l G Reference
       Region 2h1l G 260-265 disorder
       Region 2h1l G 266-627 order
 Evidence X-RAY 2h1l H Reference
       Region 2h1l H 260-265 disorder
       Region 2h1l H 266-627 order
 Evidence X-RAY 2h1l I Reference
       Region 2h1l I 260-264 disorder
       Region 2h1l I 265-627 order
 Evidence X-RAY 2h1l J Reference
       Region 2h1l J 260-265 disorder
       Region 2h1l J 266-627 order
 Evidence X-RAY 2h1l K Reference
       Region 2h1l K 260-265 disorder
       Region 2h1l K 266-627 order
 Evidence X-RAY 2h1l L Reference
       Region 2h1l L 260-264 disorder
       Region 2h1l L 265-627 order
Seq 266-627 Hetero dodecamer : Q14181
 Evidence X-RAY 4e2i A Reference
       Region 4e2i A 266-627 order
 Evidence X-RAY 4e2i B Reference
       Region 4e2i B 266-627 order
 Evidence X-RAY 4e2i C Reference
       Region 4e2i C 266-627 order
 Evidence X-RAY 4e2i D Reference
       Region 4e2i D 266-627 order
 Evidence X-RAY 4e2i E Reference
       Region 4e2i E 266-627 order
 Evidence X-RAY 4e2i F Reference
       Region 4e2i F 266-627 order
Seq 266-627 Hetero undecamer : Q14181
 Evidence X-RAY 4e2i G Reference
       Region 4e2i G 266-627 order
 Evidence X-RAY 4e2i H Reference
       Region 4e2i H 266-627 order
 Evidence X-RAY 4e2i I Reference
       Region 4e2i I 266-627 order
 Evidence X-RAY 4e2i J Reference
       Region 4e2i J 266-627 order
 Evidence X-RAY 4e2i K Reference
       Region 4e2i K 266-627 order
 Evidence X-RAY 4e2i L Reference
       Region 4e2i L 266-627 order
SeqProS possible 103-117 an extended loop region (residues 103-117) containing the LxCxE motif, which can independently bind to the Rb pocket (PMID: 11226179) Hetero trimer : IID00017Complex
       Region 1gh6 A 7-117 order
SeqProS possible 119-134 Nuclear Localization Signal (NLS) Hetero trimer : IID50009Complex
       Region 1ejl A 126-132 order
       Region 1ejl B 126-132 order
       Region 1q1t B 123-133 order
       Region 1q1s A 128-132 order
       Region 1q1s B 119-133 order
       Region 1q1t A 127-134 order
SeqProS possible 125-132 Nuclear Localization Signal (NLS) Hetero trimer : Q9C2K9
       Region 4rxh A 128-132 order
       Region 4rxh C 125-132 order
Seqphosphorylation
    701-701 Phosphothreonine; by host
    679-679 Phosphoserine; by host
    677-677 Phosphoserine; by host
    676-676 Phosphoserine; by host
    639-639 Phosphoserine; by host
    124-124 Phosphothreonine; by host
    123-123 Phosphoserine; by host
    120-120 Phosphoserine; by host
    112-112 Phosphoserine; by host
    106-106 Phosphoserine; by host
Seqacetylation
    697-697 N6-acetyllysine; by host
    1-1 N-acetylmethionine; by host
 
Prediction
NeProc
Disorder 1-5,69-137,630-684,699-708
Order 6-68,138-261,266-629,685-698
ProS 1-5,69-113,133-137
Pfam Hmmer
PF00226 12-72 9.7e-09
PF02217 137-258 1.2e-83
SEG 631-644 ,697-708
Function
Function in SwissProt
Isoform 17kT antigen targets host RBL2 for degradation and promotes cell proliferation. Transactivates host cyclin A promoter through its J domain.
Biological Process
Diagram with PDB data
LT_SV40/Kpna2MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
LT_SV40/RB1RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN