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IID90008
 UniprotP0DJ89
ProteinSecreted effector protein EspF(U)
GeneespF(U)
OrganismEscherichia coli O157:H7
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
337
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 221-267
 Evidence NMR Reference
       Region 221-267 disorder
Seqdisorder 268-300
 Evidence CD Reference
       Region 268-300 disorder
Seq 268-300 Hetero dimer : IID00269Complex
 Evidence NMR 2k42 B Reference
       Region 2k42 B 268-300 order
       Region 2k42 B 288-300 high_rmsd
Seq 268-314 Hetero dimer : IID00331Complex
 Evidence NMR 2kxc B Reference
       Region 2kxc B 268-292 disorder
       Region 2kxc B 293-309 order
       Region 2kxc B 309-309 high_rmsd
       Region 2kxc B 310-314 disorder
Seqdisorder 268-314
 Evidence NMR Reference
       Region 268-314 disorder
Seq 268-314 Hetero trimer : IID00256Complex,IID00331Complex
 Evidence NMR 2lnh C Reference
       Region 2lnh C 268-314 order
       Region 2lnh C 292-314 high_rmsd
SeqProS verified 268-300 This region is one of the EspFU fifth repeat (R475). Hetero dimer : IID00269Complex
       Region 2k42 B 268-300 order
       Region 268-300 disorder
SeqProS verified 268-314 This region is one of the EspFU fifth repeat (R475). Hetero trimer : IID00256Complex,IID00331Complex
       Region 2lnh C 268-314 order
       Region 268-314 disorder
SeqProS verified 293-309 This region is one of the EspFU fifth repeat (R475). Hetero dimer : IID00331Complex
       Region 2kxc B 293-309 order
       Region 268-314 disorder
 
Prediction
NeProc
Disorder 1-337
ProS 1-59,126-141,174-189,224-232,268-282,291-295,316-334
AlphaFold
Disorder 1-82,96-115,117-128,145-151,153-153,165-175,191-200,212-223,225-225,237-237,239-248,259-273,276-276,279-320,329-337
Order 83-95,116-116,129-144,152-152,154-164,176-190,201-211,224-224,226-236,238-238,249-258,274-275,277-278,321-328
Pfam Hmmer
PF04806 17-189 9.8e-09
SEG 39-51 ,107-118 ,154-165 ,201-212 ,248-259 ,295-306
Function
Function in SwissProt
Required for efficient pedestal formation in host epithelial cells during infection. Acts as an intermediate between Tir (via host BAIAP2) and host WASL/N-WASP. Directly binds and activates WASL/N-WASP, which stimulates actin polymerization and leads to the formation of actin pedestals at the sites of bacterial adhesion.