Search Keyword:


Search option:


IID90018
 UniprotP03406
ProteinProtein Nef
Genenef
OrganismHuman immunodeficiency virus type 1 group M subtype B
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
206
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 54-205 Hetero tetramer : IID00698Complex
 Evidence X-RAY 1efn D Reference
       Region 1efn D 54-70 disorder
       Region 1efn D 71-148 order
       Region 1efn D 149-177 disorder
       Region 1efn D 178-203 order
       Region 1efn D 204-205 disorder
 Evidence X-RAY 1efn B Reference
       Region 1efn B 54-70 disorder
       Region 1efn B 71-148 order
       Region 1efn B 149-177 disorder
       Region 1efn B 178-203 order
       Region 1efn B 204-205 disorder
Seq 58-204 Hetero tetramer : IID00698Complex
 Evidence X-RAY 4d8d D Reference
       Region 4d8d D 58-69 disorder
       Region 4d8d D 70-148 order
       Region 4d8d D 149-178 disorder
       Region 4d8d D 179-204 order
 Evidence X-RAY 4d8d B Reference
       Region 4d8d B 58-68 disorder
       Region 4d8d B 69-148 order
       Region 4d8d B 149-178 disorder
       Region 4d8d B 179-204 order
Seq 58-206 Hetero trimer : IID00698Complex
 Evidence X-RAY 1avz B Reference
       Region 1avz B 58-70 disorder
       Region 1avz B 71-148 order
       Region 1avz B 149-178 disorder
       Region 1avz B 179-203 order
       Region 1avz B 204-206 disorder
 Evidence X-RAY 1avz A Reference
       Region 1avz A 58-73 disorder
       Region 1avz A 74-148 order
       Region 1avz A 149-178 disorder
       Region 1avz A 179-203 order
       Region 1avz A 204-206 disorder
Seq 58-206 Homo dimer :
 Evidence X-RAY 1avv A Reference
       Region 1avv A 58-73 disorder
       Region 1avv A 74-147 order
       Region 1avv A 148-178 disorder
       Region 1avv A 179-203 order
       Region 1avv A 204-206 disorder
SeqProS verified 71-73 Hetero tetramer : IID00698Complex
       Region 1efn B 71-148 order
       Region 1efn D 71-148 order
       Region 1avv A 58-73 disorder
Seqphosphorylation
    6-6 Phosphoserine; by host
 
Prediction
NeProc
Disorder 1-30
Order 31-206
ProS 1-30
AlphaFold
Disorder 1-23,62-70,160-162,164-164,205-206
Order 24-61,71-159,163-163,165-204
Pfam Hmmer
PF00469 2-205 2.2e-143
SEG 42-56
Function
Function in SwissProt
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors (PubMed:14990729).