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IID90019
 UniprotP04601
ProteinProtein Nef
Genenef
OrganismHuman immunodeficiency virus type 1 group M subtype B
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
206
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 63-203 Hetero trimer : IID50129Complex,IID50215Complex
 Evidence X-RAY 4nee C Reference
       Region 4nee C 63-71 disorder
       Region 4nee C 72-203 order
 Evidence X-RAY 4nee K Reference
       Region 4nee K 63-72 disorder
       Region 4nee K 73-203 order
 Evidence X-RAY 4nee E Reference
       Region 4nee E 63-71 disorder
       Region 4nee E 72-203 order
 Evidence X-RAY 4nee H Reference
       Region 4nee H 63-73 disorder
       Region 4nee H 74-203 order
Seq 73-82 Hetero trimer : P04439
 Evidence X-RAY 3rl2 C Reference
       Region 3rl2 C 73-82 order
Seq 134-142 Hetero trimer : P04439
 Evidence X-RAY 5hga C Reference
       Region 5hga C 136-141 order
 Evidence X-RAY 5hga F Reference
       Region 5hga F 136-141 order
 Evidence X-RAY 5hgb C Reference
       Region 5hgb C 134-141 order
 Evidence X-RAY 5hgb F Reference
       Region 5hgb F 134-141 order
 Evidence X-RAY 5hgb I Reference
       Region 5hgb I 134-141 order
 Evidence X-RAY 5hgb L Reference
       Region 5hgb L 134-141 order
 Evidence X-RAY 5hgd C Reference
       Region 5hgd C 136-142 order
 Evidence X-RAY 5hgd F Reference
       Region 5hgd F 136-142 order
 Evidence X-RAY 5hgh C Reference
       Region 5hgh C 134-142 order
 Evidence X-RAY 4wu5 C Reference
       Region 4wu5 C 134-141 order
 Evidence X-RAY 4wu5 F Reference
       Region 4wu5 F 134-141 order
 Evidence X-RAY 4wu7 C Reference
       Region 4wu7 C 136-141 order
 Evidence X-RAY 4wu7 F Reference
       Region 4wu7 F 136-141 order
Seqphosphorylation
    6-6 Phosphoserine; by host
 
Prediction
NeProc
Disorder 1-30
Order 31-206
ProS 1-30
AlphaFold
Disorder 1-9,24-32,62-70,159-162,205-206
Order 10-23,33-61,71-158,163-204
Pfam Hmmer
PF00469 2-205 4.1e-141
SEG 42-56
Function
Function in SwissProt
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.