20210801 20180803 20180425 20210801 IID00131 Ski oncogene Proto-oncogene c-Ski Homo sapiens 728 P12755 Q5SYT7 May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. Nucleus. SL-0191 unkown Phosphoserine 383 383 Phosphoserine 432 432 Phosphoserine 480 480 Phosphoserine 720 720 MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELEP 1 1sbxA 91 192 order 1 2 1mr1C 219 312 order 2 3 1mr1C 313 313 disorder 2 4 1mr1D 219 312 order 2 5 1mr1D 313 313 disorder 2 1 1sbx X-RAY 298K 5.5 15130471 J.J.WILSON,M.MALAKHOVA,R.ZHANG,A.JOACHIMIAK,R.S.HEGDE CRYSTAL STRUCTURE OF THE DACHSHUND HOMOLOGY DOMAIN OF HUMAN SKI 2004 STRUCTURE 12 785 x-ray 1sbx A 91 192 100 0 1 1sbx_1 3043 Monomer monomer 1sbxA P12755 IID00131 2 1mr1 X-RAY 295K 7.5 12419246 J.-W.WU,A.R.KRAWITZ,J.CHAI,W.LI,F.ZHANG,K.LUO,Y.SHI STRUCTURAL MECHANISM OF SMAD4 RECOGNITION BY THE NUCLEAR ONCOPROTEIN SKI: INSIGHTS ON SKI-MEDIATED REPRESSION OF TGF-BETA SIGNALING 2002 CELL(CAMBRIDGE,MASS.) 111 357 x-ray 1mr1 C 219 313 100 1 313 313 x-ray 1mr1 D 219 313 100 1 313 313 1 1mr1_1 1373 Hetero dimer 1mr1D P12755 IID00131 1mr1A Q13485 IID00132 1mr1D-1mr1A 2 1mr1_2 1373 Hetero dimer 1mr1C P12755 IID00131 1mr1B Q13485 IID00132 1mr1C-1mr1B 94-192,218-312 1-93,193-217,313-550,669-728 551-668 406 PF02437 88->190 3.9e-49 SKI/SNO/DAC family hmm pfm 407 PF08782 217->311 7e-43 c-SKI Smad4 binding domain hmm pfm 3287 1mr1C_ 217->312 5.6e-45 SAND domain-like hmm scp 3288 1sbxA_ 88->191 6.9e-43 Putative DNA-binding domain hmm scp 5632 PF02437 93->187 1e-27 SKI/SNO/DAC family rps pfm 5633 PF08782 217->311 9e-33 c-SKI Smad4 binding domain rps pfm 5634 PF12128 532->709 5e-14 Protein of unknown function (DUF3584) rps pfm 8207 1sbxA1 91->192 1e-40 rps scp 8208 1mr1C1 219->312 8e-40 rps scp 8209 1f5nA1 485->674 9e-05 rps scp