STRUCTURE OF A HOXB1-PBX1 HETERODIMER BOUND TO DNA: ROLE OF THE HEXAPEPTIDE AND A FOURTH HOMEODOMAIN HELIX IN COMPLEX FORMATION.

20210801 20180803 20180425 20210801 IID00142 Homeobox protein Hox-B1 Homeobox protein Hox-2I Homo sapiens 301 P14653 Q4VB03 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Nucleus. SL-0191 unkown Antp-type hexapeptide 179 184 0 0 MDYNRMNSFLEYPLCNRGPSAYSAHSAPTSFPPSSAQAVDSYASEGRYGGGLSSPAFQQNSGYPAQQPPSTLGVPFPSSAPSGYAPAACSPSYGPSQYYPLGQSEGDGGYFHPSSYGAQLGGLSDGYGAGGAGPGPYPPQHPPYGNEQTASFAPAYADLLSEDKETPCPSEPNTPTARTFDWMKVKRNPPKTAKVSEPGLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKREREEGRVPPAPPGCPKEAAGDASDQSTCTSPEASPSSVTS 2 1b72A 177 185 order 1 3 1b72A 186 205 disorder 1 4 1b72A 206 264 order 1 5 1b72A 170 176 disorder 1 1 1b72 X-RAY 8 10052460 D.E.PIPER,A.H.BATCHELOR,C.P.CHANG,M.L.CLEARY,C.WOLBERGER STRUCTURE OF A HOXB1-PBX1 HETERODIMER BOUND TO DNA: ROLE OF THE HEXAPEPTIDE AND A FOURTH HOMEODOMAIN HELIX IN COMPLEX FORMATION. 1999 CELL(CAMBRIDGE,MASS.) 96 587 x-ray 1b72 A 170 264 98 2 170 176 186 205 1 1b72_1 1839 Hetero dimer 1b72A P14653 IID00142 1b72B P40424 IID00149 1b72A-1b72B 177-253 1-176,254-301 429 PF00046 207->260 4.7e-26 Homeodomain hmm pfm 3305 1b72A_ 196->263 1e-26 hmm scp 5656 PF00046 207->259 8e-08 Homeodomain rps pfm 8229 1p7iD 207->257 8e-28 rps scp