20210801 20180803 20180328 20210801 IID00149 Pre-B-cell leukemia transcription factor 1 Homeobox protein PBX1 Homeobox protein PRL Homo sapiens 430 P40424 B4DSC1 F5H4U9 Q5T488 Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression. Nucleus. SL-0191 unkown MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN 1 1pufB 233 305 order 1 2 1b72B 233 234 disorder 2 3 1b72B 235 307 order 2 4 1b72B 308 319 disorder 2 1 1puf X-RAY 292K 7.5 12923056 N.A.LARONDE-LEBLANC,C.WOLBERGER STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR 2003 GENES DEV. 17 2060 x-ray 1puf B 233 305 100 0 1 1puf_1 2930 Hetero dimer 1pufA P09631 IID50023 1pufB P40424 IID00149 1pufA-1pufB 2 1b72 X-RAY 8 10052460 D.E.PIPER,A.H.BATCHELOR,C.P.CHANG,M.L.CLEARY,C.WOLBERGER STRUCTURE OF A HOXB1-PBX1 HETERODIMER BOUND TO DNA: ROLE OF THE HEXAPEPTIDE AND A FOURTH HOMEODOMAIN HELIX IN COMPLEX FORMATION. 1999 CELL(CAMBRIDGE,MASS.) 96 587 x-ray 1b72 B 233 319 100 2 233 234 308 319 1 1b72_1 1839 Hetero dimer 1b72A P14653 IID00142 1b72B P40424 IID00149 1b72A-1b72B 233-305 1-232,306-430 438 PF03792 40->232 2.8e-98 PBC domain hmm pfm 439 PF00046 234->293 5.1e-23 Homeodomain hmm pfm 3314 1lfuP_ 233->301 7.4e-23 hmm scp 5667 PF03792 91->232 3e-51 PBC domain rps pfm 5668 PF05920 252->290 7e-08 Homeobox KN domain rps pfm 8238 1pufB 233->305 2e-33 rps scp