20210801 20180803 20180425 20210801 IID00175 POU domain class 2-associating factor 1 B-cell-specific coactivator OBF-1 OCA-B OCT-binding factor 1 BOB-1 Homo sapiens 256 Q16633 B2R8Z9 Q14983 Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). Nucleus. SL-0191 unkown POU2AF1 OBF1_HUMAN MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAAPAPTAVVLPHQPLATYTTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPWTPYTEYVPHEAVSCPYSADMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPAVGPPLEGPEHQAPLTYFPWPQPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQDMEDPRRAASSLTIDKLLLEEEDSDAYALNHTLSVEGF 1 1cqtI 1 15 disorder 1 2 1cqtI 16 37 order 1 3 1cqtI 38 44 disorder 1 4 1cqtJ 1 15 disorder 1 5 1cqtJ 16 38 order 1 6 1cqtJ 39 44 disorder 1 7 1 65 disorder 2 8 1 256 disorder 3 1 1cqt X-RAY 293K 7.5 10541551 D.CHASMAN,K.CEPEK,P.A.SHARP,C.O.PABO CRYSTAL STRUCTURE OF AN OCA-B PEPTIDE BOUND TO AN OCT-1 POU DOMAIN/OCTAMER DNA COMPLEX: SPECIFIC RECOGNITION OF A PROTEIN-DNA INTERFACE. 1999 GENES DEV. 13 2650 x-ray 1cqt I 1 44 100 2 1 15 38 44 x-ray 1cqt J 1 44 100 2 1 15 39 44 1 1cqt_1 1000 Hetero dimer 1cqtA P14859 IID00144 1cqtI Q16633 IID00175 1cqtA-1cqtI 2 1cqt_2 1000 Hetero dimer 1cqtB P14859 IID00144 1cqtJ Q16633 IID00175 1cqtJ-1cqtB 2 none CD 10329190 Chang JF, Phillips K, Lundback T, Gstaiger M, Ladbury JE, Luisi B. Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding. 1999 J Mol Biol. 288 941-52. 3 none CD, SAXS, NMR 11380252 Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B. Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator. 2001 Biochemistry 40 6580-8 ProS 1 verified 2,5 16 38 7 1 65
Q16633-1 POU2AF1/POU2F1/DNA CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT
13-36,121-136,178-178,231-237 1-12,37-120,137-177,179-230,238-256 17-23 1-16,24-256 1-4,24-40,50-56,80-89,96-110,119-151,163-189,202-211,229-256