20210801 20180803 20180425 20210801 IID00197 Paired box protein Pax-6 Oculorhombin Aniridia type II protein Homo sapiens 422 P26367 Q6N006 Q99413 Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity). Nucleus. SL-0191 unkown PAX6 PAX6_HUMAN MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ 1 2cueA 211 277 order 1 2 6paxA 4 136 order 2 3 2cueA 211 213 high_rmsd 1 4 2cueA 277 277 high_rmsd 1 1 2cue NMR S.OHNISHI,T.KIGAWA,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMA TO BE PUBLISHED nmr 2cue A 211 277 100 0 1 2cue 3518 Monomer monomer 2cueA P26367 IID00197 2 6pax X-RAY 8 10346815 H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABO 1999 GENES DEV. 13 1263 x-ray 6pax A 4 136 97 0 1 6pax_1 2909 Monomer monomer 6paxA P26367 IID00197 5-134,214-275 1-4,135-213,276-422 7-132,201-228 1-6,133-200,229-422 1-6,133-145,164-200,229-258,367-374,393-408,415-422 174-185,203-212,281-294,387-395,398-412