20210801 20180803 20180328 20210801 IID00206 Protein Dr1 Down-regulator of transcription 1 TATA-binding protein-associated phosphoprotein Negative cofactor 2-beta Homo sapiens 176 Q01658 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Nucleus. SL-0191 unkown Nuclear localization signal 100 103 N-acetylalanine 2 2 Phosphoserine 105 105 Phosphoserine 106 106 Phosphoserine 166 166 Phosphoserine 167 167 DR1 NC2B_HUMAN MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI 1 1jfiB 1 8 disorder 1 2 1jfiB 9 143 order 1 3 1jfiB 144 176 disorder 1 1 1jfi X-RAY 293K 5.5 11461703 K.KAMADA,F.SHU,H.CHEN,S.MALIK,G.STELZER,R.G.ROEDER,M.MEISTERERNST,S.K.BURLEY 2001 CELL(CAMBRIDGE,MASS.) 106 71 x-ray 1jfi B 1 176 100 2 1 8 144 176 1 1jfi_1 2387 Hetero trimer 1jfiB Q01658 IID00206 1jfiA Q14919 IID00385 1jfiC P20226 IID00367 1jfiB-1jfiC 1jfiB-1jfiA 1jfiA-1jfiC ProS 1 possible 2 80 143 The region of helix4 and 5 (80-143) is highly likely a random coil in the absence of TBP and DNA. 10-160 1-9,161-176 10-56,61-99,115-142 1-9,57-60,100-114,143-176 57-60,103-114,143-144,172-176 115-125,127-168