20210801 20180803 20180228 20210801 IID00343 SPRY domain-containing SOCS box protein 1 Homo sapiens 273 Q96BD6 A2A275 Q59FA1 Q5TIH9 Q9BRY9 Q9H6C5 Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Cytoplasm. SL-0086 unkown 0 0 Phosphotyrosine; by MET 31 31 MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ 2 3f2oA 31 233 order 2 6 2jk9A 30 231 order 1 8 3f2oB 31 233 order 2 1 2jk9 X-RAY 5.5 20561531 P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,A.BULLOCK 2010 J.MOL.BIOL. 401 389 x-ray 2jk9 A 30 231 100 0 1 2jk9_1 2399 Hetero dimer 2jk9A Q96BD6 IID00343 2jk9B Q96IZ0 IID00177 2jk9A-2jk9B 2 3f2o X-RAY 277K 5.5 20561531 P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,A.N.BULLOCK 2010 J.MOL.BIOL. 401 389 x-ray 3f2o A 31 233 100 0 x-ray 3f2o B 31 233 100 0 1 3f2o_1 1088 Hetero dimer 3f2oA Q96BD6 IID00343 3f2oC P09052 3f2oA-3f2oC 2 3f2o_2 1088 Hetero dimer 3f2oB Q96BD6 IID00343 3f2oD P09052 3f2oB-3f2oD 30-273 1-29 1015 PF00622 98->220 3.2e-23 SPRY domain hmm pfm 1016 PF07525 234->272 1.8e-14 SOCS box hmm pfm 3757 2fnjA1 32->246 3.3e-70 hmm scp 3758 2c9wA1 230->272 2.7e-08 hmm scp 6163 PF07525 236->270 3e-05 SOCS box rps pfm 8668 2fnjA1 31->246 5e-67 rps scp 8669 2izvA1 234->272 7e-05 rps scp