20210801 20180803 20180228 20210801 IID00343 SPRY domain-containing SOCS box protein 1 Homo sapiens 273 Q96BD6 A2A275 Q59FA1 Q5TIH9 Q9BRY9 Q9H6C5 Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Cytoplasm. SL-0086 unkown 0 0 Phosphotyrosine; by MET 31 31 SPSB1 SPSB1_HUMAN MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ 2 3f2oA 31 233 order 2 6 2jk9A 30 231 order 1 8 3f2oB 31 233 order 2 1 2jk9 X-RAY 5.5 20561531 P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,A.BULLOCK 2010 J.MOL.BIOL. 401 389 x-ray 2jk9 A 30 231 100 0 1 2jk9_1 2399 Hetero dimer 2jk9A Q96BD6 IID00343 2jk9B Q96IZ0 IID00177 2jk9A-2jk9B 2 3f2o X-RAY 277K 5.5 20561531 P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,A.N.BULLOCK 2010 J.MOL.BIOL. 401 389 x-ray 3f2o A 31 233 100 0 x-ray 3f2o B 31 233 100 0 1 3f2o_1 1088 Hetero dimer 3f2oA Q96BD6 IID00343 3f2oC P09052 3f2oA-3f2oC 2 3f2o_2 1088 Hetero dimer 3f2oB Q96BD6 IID00343 3f2oD P09052 3f2oB-3f2oD 10-16,31-273 1-9,17-30 20-273 1-19 1-12