INSIGHT INTO E-SELECTIN/LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC/EGF DOMAINS.

20210801 20180803 20180228 20210801 IID00351 E-selectin CD62 antigen-like family member E Endothelial leukocyte adhesion molecule 1 Leukocyte-endothelial cell adhesion molecule 2 Homo sapiens 610 P16581 A2RRD6 P16111 Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. Cell membrane. SL-0039 unkown 0 0 0 0 SELE LYAM2_HUMAN MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL 1 1eslA 22 178 order 1 2 1eslA 179 183 disorder 1 3 1g1tA 22 178 order 2 4 4csyA 22 301 order 3 5 4csyB 22 301 order 3 6 4c16A 22 301 order 4 7 4c16B 22 301 order 4 1 1esl X-RAY 7509040 B.J.GRAVES,R.L.CROWTHER,C.CHANDRAN,J.M.RUMBERGER,S.LI,K.S.HUANG,D.H.PRESKY,P.C.FAMILLETTI,B.A.WOLITZKY,D.K.BURNS INSIGHT INTO E-SELECTIN/LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC/EGF DOMAINS. 1994 NATURE 367 532 x-ray 1esl A 22 183 100 1 179 183 1 1esl_1 1072 Monomer monomer 1eslA P16581 IID00351 2 1g1t X-RAY 7.5 11081633 W.S.SOMERS,J.TANG,G.D.SHAW,R.T.CAMPHAUSEN INSIGHTS INTO THE MOLECULAR BASIS OF LEUKOCYTE TETHERING AND ROLLING REVEALED BY STRUCTURES OF P- AND E-SELECTIN BOUND TO SLE(X) AND PSGL-1. 2000 CELL(CAMBRIDGE,MASS.) 103 467 x-ray 1g1t A 22 178 100 0 1 1g1t_1 1072 Monomer monomer 1g1tA P16581 IID00351 3 4csy X-RAY 6.2 26117840 R.C.PRESTON,R.P.JAKOB,F.P.BINDER,C.P.SAGER,B.ERNST,T.MAIER E-SELECTIN LIGAND COMPLEXES ADOPT AN EXTENDED HIGH-AFFINITY CONFORMATION. 2016 J.MOL.CELL.BIOL. 8 62 x-ray 4csy A 22 301 100 0 x-ray 4csy B 22 301 100 0 1 4csy_2 474 Monomer monomer 4csyB P16581 IID00351 2 4csy_1 474 Monomer monomer 4csyA P16581 IID00351 4 4c16 X-RAY 6.2 26117840 R.C.PRESTON,R.P.JAKOB,F.P.BINDER,C.P.SAGER,B.ERNST,T.MAIER E-SELECTIN LIGAND COMPLEXES ADOPT AN EXTENDED HIGH-AFFINITY CONFORMATION. 2016 J.MOL.CELL.BIOL. 8 62 x-ray 4c16 A 22 301 100 0 x-ray 4c16 B 22 301 100 0 1 4c16_2 474 Monomer monomer 4c16B P16581 IID00351 2 4c16_1 474 Monomer monomer 4c16A P16581 IID00351 21-256,260-382,387-498,500-550 1-20,257-259,383-386,499-499,551-610 6-596,601-610 1-5,597-600 1-5,597-600 557-572