20210801 20180803 20180228 20210801 IID00388 Kinetochore protein Spc24 Homo sapiens 197 Q8NBT2 B4DZZ7 C9JGC4 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Chromosome, Centromere, Kinetochore. SL-0149 unkown Nucleus. SL-0191 unkown 0 0 Phosphoserine 11 11 SPC24 SPC24_HUMAN MAAFRDIEEVSQGLLSLLGANRAEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLYLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVSKIEWDYECEPGMVKGIHHGPSVAQPIHLDSTQLSRKFISDYLWSLVDTEW 1 2ve7C 122 132 disorder 1 2 2ve7C 133 164 order 1 3 2ve7C 165 170 disorder 1 4 2ve7C 171 193 order 1 5 2ve7C 194 197 disorder 1 6 2ve7D 122 197 order 1 1 2ve7 X-RAY 7.5 18455984 C.CIFERRI,S.PASQUALATO,E.SCREPANTI,G.VARETTI,S.SANTAGUIDA,G.DOS REIS,A.MAIOLICA,J.POLKA,J.G.DE LUCA,P.DE WULF,M.SALEK,J.RAPPSILBER,C.A.MOORES,E.D.SALMON,A.MUSACCHIO 2008 CELL(CAMBRIDGE,MASS.) 133 427 x-ray 2ve7 C 122 197 98 3 122 132 165 170 194 197 x-ray 2ve7 D 122 197 98 0 1 2ve7_1 4909 Hetero dimer 2ve7C Q8NBT2 IID00388 2ve7C Q9BZD4 IID00393 2ve7A O14777 IID00184 2ve7A Q9HBM1 IID00395 2ve7A-2ve7C 2ve7A-2ve7A 2ve7C-2ve7A 2ve7C-2ve7C 2 2ve7_2 4910 Hetero dimer 2ve7D Q8NBT2 IID00388 2ve7D Q9BZD4 IID00393 2ve7B O14777 IID00184 2ve7B Q9HBM1 IID00395 2ve7D-2ve7D 2ve7D-2ve7B 2ve7B-2ve7B 2ve7B-2ve7D 6-197 1-5 1-32,66-197 33-65 33-65