20210801 20180803 20180328 20210801 IID00442 Cyclic AMP-responsive element-binding protein 1 Homo sapiens 341 P16220 P21934 Q6V963 Q9UMA7 Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Nucleus. SL-0191 unkown 0 0 Phosphoserine; by CaMK1, CaMK2, CaMK4, PKB/AKT1 or PKB/AKT2, RPS6KA3, RPS6KA4, RPS6KA5 and SGK1 133 133 Phosphoserine 142 142 Phosphoserine; by HIPK2 271 271 CREB1 CREB1_HUMAN MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD 1 2lxtC 116 149 order 1 2 2lxtC 116 120 high_rmsd 1 3 2lxtC 146 149 high_rmsd 1 1 2lxt NMR 23651431 S.BRUSCHWEILER,R.KONRAT,M.TOLLINGER ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGH DYNAMIC REPACKING OF THE HYDROPHOBIC CORE. 2013 ACS CHEM.BIOL. nmr 2lxt C 116 149 97 0 1 2lxt_1 2613 Hetero trimer 2lxtC P16220 IID00442 2lxtA Q92793 IID00092 2lxtB Q03164 IID00379 2lxtC-2lxtB 2lxtC-2lxtA 2lxtA-2lxtB ProS 1 possible 1 121 145 The rat pKID region (P15337, 100 0dentity) is disordered in the free state.
P16220-1 CREB1/CRBBP/KMT2A Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core
104-129,158-172,174-175,177-180,215-215,232-232,234-234,236-239,264-326 1-103,130-157,173-173,176-176,181-214,216-231,233-233,235-235,240-263,327-327 275-326 1-274,327-327 24-29,65-69,85-91,121-138,160-177,187-192,204-210,218-231,269-274 93-108,138-145,148-160,278-292