20210801 20180803 20180328 20210801 IID00477 Transcription factor NF-E2 45 kDa subunit Leucine zipper protein NF-E2 Nuclear factor, erythroid-derived 2 45 kDa subunit p45 NF-E2 Homo sapiens 373 Q16621 Q07720 Q6ICV9 Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. Cytoplasm. SL-0086 unkown Nucleus, PML body. SL-0465 reported PXY motif 1 61 65 PXY motif 2 79 83 Phosphoserine; by MAPK8 157 157 Phosphoserine; by PKA 170 170 MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPRGTKMEATD 1 2kz5A 214 293 order 1 2 2kz5A 214 220 high_rmsd 1 3 2kz5A 284 293 high_rmsd 1 1 2kz5 NMR G.LIU,H.JANJUA,R.XIAO,C.CICCOSANTI,R.SHASTRY,T.B.ACTON,S.TONG,J.K.EVERETT,G.T.MONTELIONE TO BE PUBLISHED nmr 2kz5 A 214 293 98 0 1 2kz5_1 2478 Monomer monomer 2kz5A Q16621 IID00477 214-326 1-213,363-373 327-362 1402 PF03131 239->329 8.2e-21 bZIP Maf transcription factor hmm pfm 4050 1sknP_ 224->290 3.3e-28 hmm scp 4051 1t2kC_ 268->326 2.7e-13 Leucine zipper domain hmm scp 6520 PF03131 237->330 7e-18 bZIP Maf transcription factor rps pfm 8944 1sknP 224->294 2e-25 rps scp