20210801 20180803 20180328 20210801 IID00477 Transcription factor NF-E2 45 kDa subunit Leucine zipper protein NF-E2 Nuclear factor, erythroid-derived 2 45 kDa subunit p45 NF-E2 Homo sapiens 373 Q16621 Q07720 Q6ICV9 Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. Cytoplasm. SL-0086 unkown Nucleus, PML body. SL-0465 reported PXY motif 1 61 65 PXY motif 2 79 83 Phosphoserine; by MAPK8 157 157 Phosphoserine; by PKA 170 170 NFE2 NFE2_HUMAN MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPRGTKMEATD 1 2kz5A 214 293 order 1 2 2kz5A 214 220 high_rmsd 1 3 2kz5A 284 293 high_rmsd 1 1 2kz5 NMR G.LIU,H.JANJUA,R.XIAO,C.CICCOSANTI,R.SHASTRY,T.B.ACTON,S.TONG,J.K.EVERETT,G.T.MONTELIONE TO BE PUBLISHED nmr 2kz5 A 214 293 98 0 1 2kz5_1 2478 Monomer monomer 2kz5A Q16621 IID00477 22-33,60-60,223-365 1-21,34-59,61-222,366-373 226-365 1-225,366-373 21-50,64-75,83-102,114-133,139-164,170-181,212-225,370-373 50-68,77-86,105-120,171-182,294-317