20210801 20180803 20180228 20210801 IID00507 SH3 domain-binding protein 5 SH3 domain-binding protein that preferentially associates with BTK Homo sapiens 455 O60239 B3KQW6 Q5JWV9 Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Mitochondrion. SL-0173 unkown 0 0 Phosphoserine; by MAPK12 and MAPK9 351 351 Phosphoserine 375 375 Phosphoserine 376 376 Phosphoserine 418 418 Phosphoserine 421 421 SH3BP5 3BP5_HUMAN MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGAENKTSDKANNNRGLSSSSGSGGSSKSQSSTSPEGQALENRMKQLSLQCSKGRDGIIADIKMVQIG 1 4h3bB 341 350 order 1 2 4h3bD 341 350 order 1 1 4h3b X-RAY 294.0K 5.5 23142346 J.D.LAUGHLIN,J.C.NWACHUKWU,M.FIGUERA-LOSADA,L.CHERRY,K.W.NETTLES,P.V.LOGRASSO 2012 STRUCTURE 20 2174 x-ray 4h3b B 341 350 100 0 x-ray 4h3b D 341 350 100 0 1 4h3b_1 1168 Hetero dimer 4h3bA P53779 IID00456 4h3bB O60239 IID00507 4h3bA-4h3bB 2 4h3b_2 1168 Hetero dimer 4h3bC P53779 IID00456 4h3bD O60239 IID00507 4h3bD-4h3bC 40-265 1-39,266-455 40-256 1-39,257-455 36-39,257-275,284-309,352-369,385-402,424-455 23-40,320-332,403-421