20210801 20180803 20180328 20210801 IID00557 Fibroblast growth factor 8 Androgen-induced growth factor Heparin-binding growth factor 8 Homo sapiens 233 P55075 A1A514 Q14915 Q15766 Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). Secreted. SL-0243 unkown 0 0 0 0 FGF8 FGF8_HUMAN MGSPRSALSCLLLHLLVLCLQAQEGPGRGPALGRELASLFRAGREPQGVSQQHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR 1 2fdbM 52 198 order 1 2 2fdbM 199 204 disorder 1 3 2fdbN 52 197 order 1 4 2fdbN 198 204 disorder 1 1 2fdb X-RAY 293K 7.5 16384934 S.K.OLSEN,J.Y.H.LI,C.BROMLEIGH,A.V.ELISEENKOVA,O.A.IBRAHIMI,Z.LAO,F.ZHANG,R.J.LINHARDT,A.L.JOYNER,M.MOHAMMADI 2006 GENES DEV. 20 185 x-ray 2fdb M 52 204 100 1 199 204 x-ray 2fdb N 52 204 100 1 198 204 1 2fdb_1 1102 Hetero dimer 2fdbP P21802 IID00546 2fdbM P55075 IID00557 2fdbP-2fdbM 2 2fdb_2 1102 Hetero dimer 2fdbR P21802 IID00546 2fdbN P55075 IID00557 2fdbN-2fdbR 15-18,50-199 1-14,19-49,200-233 62-182 1-61,183-233 7-42,52-61,183-201,207-216 8-20