20210801 20180803 20180425 20210801 IID00584 Sclerostin Homo sapiens 213 Q9BQB4 Q495N9 Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Secreted, Extracellular space, Extracellular matrix. SL-0111 unkown 0 0 0 0 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY 2 3sovZ 115 121 order 2 3 2k8pA 25 79 disorder 1 4 2k8pA 80 109 order 1 5 2k8pA 110 137 disorder 1 6 2k8pA 138 168 order 1 7 2k8pA 169 213 disorder 1 8 2k8pA 25 78 high_rmsd 1 9 2k8pA 112 131 high_rmsd 1 10 2k8pA 171 213 high_rmsd 1 1 2k8p NMR 19208630 V.VEVERKA,A.J.HENRY,P.M.SLOCOMBE,A.VENTOM,B.MULLOY,F.W.MUSKETT,M.MUZYLAK,K.GREENSLADE,A.MOORE,L.ZHANG,J.GONG,X.QIAN,C.PASZTY,R.J.TAYLOR,M.K.ROBINSON,M.D.CARR CHARACTERIZATION OF THE STRUCTURAL FEATURES AND INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTO A KEY REGULATOR OF WNT-MEDIATED BONE FORMATION 2009 J.BIOL.CHEM. 284 10890 nmr 2k8p A 25 213 100 0 1 2k8p 3722 Monomer monomer 2k8pA Q9BQB4 IID00584 2 3sov X-RAY 277K 8 21944579 E.BOURHIS,W.WANG,C.TAM,J.HWANG,Y.ZHANG,D.SPITTLER,O.W.HUANG,Y.GONG,A.ESTEVEZ,I.ZILBERLEYB,L.ROUGE,C.CHIU,Y.WU,M.COSTA,R.N.HANNOUSH,Y.FRANKE,A.G.COCHRAN WNT ANTAGONISTS BIND THROUGH A SHORT PEPTIDE TO THE FIRST BETA-PROPELLER DOMAIN OF LRP5/6. 2011 STRUCTURE 19 1433 x-ray 3sov Z 115 121 100 0 1 3sov_1 3053 Hetero dimer 3sovA O75581 IID00531 3sovZ Q9BQB4 IID00584 3sovA-3sovZ ProS 1 verified 2 115 121 5 110 137 25-213 1-24 1679 PF05463 3->210 2.1e-96 Sclerostin (SOST) hmm pfm 6780 PF05463 24->209 2e-59 Sclerostin (SOST) rps pfm