20250201 20180803 20180228 20250201 IID00585 Protein sprouty homolog 4 Homo sapiens 299 Q9C004 A4FVB2 A4FVB3 Q6QIX2 Q9C003 Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). Cytoplasm. SL-0086 unkown Cell projection, Ruffle membrane. SL-0301 unkown 0 0 N-acetylmethionine 1 1 Phosphoserine 125 125 SPRY4 Protein sprouty homolog 4 MEPPIPQSAPLTPNSVMVQPLLDSRMSHSRLQHPLTILPIDQVKTSHVENDYIDNPSLALTTGPKRTRGGAPELAPTPARCDQDVTHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPVADQASPRAVRIQPKVVHCQPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDAKTSRPDKPF 1 3bunA 46 49 disorder 1 2 3bunA 50 56 order 1 3 3bunA 57 58 disorder 1 1 3bun X-RAY 298K 7.5 18273061 C.NG,R.A.JACKSON,J.P.BUSCHDORF,Q.SUN,G.R.GUY,J.SIVARAMAN 2008 EMBO J. 27 804 x-ray 3bun A 46 58 92 2 46 49 57 58 1 3bun 4538 Hetero dimer 3bunB P22681 IID00300 3bunA Q9C004 IID00585 3bunB-3bunA ProS 1 predicted 2 50 56 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. 38-38,40-40,43-43,154-211,218-227,229-285 1-37,39-39,41-42,44-153,212-217,228-228,286-299 155-218,225-282 1-154,219-224,283-299 20-58,125-132,219-224,283-286,296-299 91-107,159-171