NMR SOLUTION STRUCTURE OF THE TANDEM SRC HOMOLOGY 3 DOMAINS OF P47PHOX COMPLEXED WITH A P22PHOX-DERIVED PROLINE-RICH PEPTIDE

20210801 20180803 20180425 20210801 IID00596 Cytochrome b-245 light chain Cytochrome b(558) alpha chain Cytochrome b558 subunit alpha Neutrophil cytochrome b 22 kDa polypeptide Superoxide-generating NADPH oxidase light chain subunit p22 phagocyte B-cytochrome p22-phox Homo sapiens 195 P13498 Q14090 Q9BR72 Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Cell membrane. SL-0039 unkown 0 0 Phosphothreonine 147 147 Phosphoserine 168 168 MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVFVCLLEYPRGKRKKGSTMERWGQKYMTAVVKLFGPFTRNYYVRAVLHLLLSVPAGFLLATILGTACLAIASGIYLLAAVRGEQWTPIEPKPRERPQIGGTIKQPPSNPPPRPPAEARKKPSEEEAAVAAGGPPGGPQVNPIPVTDEVV 1 1wlpA 149 168 order 1 1 1wlp NMR 16326715 K.OGURA,I.NOBUHISA,S.YUZAWA,R.TAKEYA,S.TORIKAI,K.SAIKAWA,H.SUMIMOTO,F.INAGAKI NMR SOLUTION STRUCTURE OF THE TANDEM SRC HOMOLOGY 3 DOMAINS OF P47PHOX COMPLEXED WITH A P22PHOX-DERIVED PROLINE-RICH PEPTIDE 2006 J.BIOL.CHEM. 281 3660 nmr 1wlp A 149 168 100 0 1 1wlp 3958 Hetero dimer 1wlpB P14598 IID00597 1wlpA P13498 IID00596 1wlpA-1wlpB ProS 1 predicted 2 149 168 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). 1-7,54-69,132-195 8-53,70-131 1706 PF05038 2->193 1.7e-107 Cytochrome Cytochrome b558 alpha-subunit hmm pfm 6807 PF05038 2->192 4e-73 Cytochrome Cytochrome b558 alpha-subunit rps pfm