20210801 20180803 20180328 20210801 IID00611 BRCA1-associated ATM activator 1 BRCA1-associated protein required for ATM activation protein 1 Homo sapiens 821 Q6PJG6 A4D200 C9JY24 Q8IW85 Q8IZ43 Q8WVR8 Q96IV9 Q9H7J8 Q9UFA3 Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). Cytoplasm. SL-0086 unkown Nucleus. SL-0191 unkown 0 0 Phosphoserine 742 742 MDPECAQLLPALCAVLVDPRQPVADDTCLEKLLDWFKTVTEGESSVVLLQEHPCLVELLSHVLKVQDLSSGVLSFSLRLAGTFAAQENCFQYLQQGELLPGLFGEPGPLGRATWAVPTVRSGWIQGLRSLAQHPSALRFLADHGAVDTIFSLQGDSSLFVASAASQLLVHVLALSMRGGAEGQPCLPGGDWPACAQKIMDHVEESLCSAATPKVTQALNVLTTTFGRCQSPWTEALWVRLSPRVACLLERDPIPAAHSFVDLLLCVARSPVFSSSDGSLWETVARALSCLGPTHMGPLALGILKLEHCPQALRTQAFQVLLQPLACVLKATVQAPGPPGLLDGTADDATTVDTLLASKSSCAGLLCRTLAHLEELQPLPQRPSPWPQASLLGATVTVLRLCDGSAAPASSVGGHLCGTLAGCVRVQRAALDFLGTLSQGTGPQELVTQALAVLLECLESPGSSPTVLKKAFQATLRWLLSSPKTPGCSDLGPLIPQFLRELFPVLQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCALLASEVPQLALQLLQDPESYVRASAVTAMGQLSSQGLHAPTSPEHAEARQSLFLELLHILSVDSEGFPRRAVMQVFTEWLRDGHADAAQDTEQFVATVLQAASRDLDWEVRAQGLELALVFLGQTLGPPRTHCPYAVALPEVAPAQPLTEALRALCHVGLFDFAFCALFDCDRPVAQKSCDLLLFLRDKIASYSSLREARGSPNTASAEATLPRWRAGEQAQPPGDQEPEAVLAMLRSLDLEGLRSTLAESSDHVEKSPQSLLQDMLATGGFLQGDEADCY 1 4ifiB 268 273 order 1 1 4ifi X-RAY 293K 4.8 24073851 X.LIU,J.A.LADIAS 2013 BIOCHEMISTRY 52 7618 x-ray 4ifi B 268 273 83 0 1 4ifi_1 2321 Hetero dimer 4ifiA P38398 IID00042 4ifiB Q6PJG6 IID00611 4ifiA-4ifiB 497-662 173-191,338-354,403-417,731-821 1-172,192-337,355-402,418-496,663-730 1744 PF02985 501->530 4.1e-09 HEAT repeat hmm pfm 1745 PF02985 547->574 3e-07 HEAT repeat hmm pfm 4306 1qgrA_ 7->675 1.8e-34 hmm scp 9195 1b3uA 302->668 5e-09 rps scp