20210801 20180803 20180328 20210801 IID00637 Ubiquitin-conjugating enzyme E2 H (E3-independent) E2 ubiquitin-conjugating enzyme H E2 ubiquitin-conjugating enzyme H UbcH2 Ubiquitin carrier protein H Ubiquitin-conjugating enzyme E2-20K Ubiquitin-protein ligase H Homo sapiens 183 P62256 A4D1L6 C9JY93 P37286 Q7Z6F4 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. 0 0 N6-acetyllysine 60 60 MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL 1 2z5dA 1 3 disorder 1 2 2z5dA 4 155 order 1 3 2z5dA 156 160 disorder 1 4 2z5dB 1 5 disorder 1 5 2z5dB 6 156 order 1 6 2z5dB 157 160 disorder 1 1 2z5d X-RAY 290K 5.5 22496338 Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANON 2012 MOL.CELL PROTEOMICS 11 329 x-ray 2z5d A 1 160 99 2 1 3 156 160 x-ray 2z5d B 1 160 99 2 1 5 157 160 1 2z5d_1 3410 Homo dimer 2z5dB P62256 IID00637 2z5dA P62256 IID00637 2z5dB-2z5dA 4-155 1-3,156-183 1794 PF00179 30->144 8.2e-42 Ubiquitin-conjugating enzyme hmm pfm 4353 1yh6A1 5->151 1.8e-47 UBC-like hmm scp 9234 1yf9A1 8->159 2e-55 rps scp