20210801 20180803 20180328 20210801 IID00637 Ubiquitin-conjugating enzyme E2 H (E3-independent) E2 ubiquitin-conjugating enzyme H E2 ubiquitin-conjugating enzyme H UbcH2 Ubiquitin carrier protein H Ubiquitin-conjugating enzyme E2-20K Ubiquitin-protein ligase H Homo sapiens 183 P62256 A4D1L6 C9JY93 P37286 Q7Z6F4 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613). 0 0 N6-acetyllysine 60 60 UBE2H UBE2H_HUMAN MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL 1 2z5dA 1 3 disorder 1 2 2z5dA 4 155 order 1 3 2z5dA 156 160 disorder 1 4 2z5dB 1 5 disorder 1 5 2z5dB 6 156 order 1 6 2z5dB 157 160 disorder 1 1 2z5d X-RAY 290K 5.5 22496338 Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANON 2012 MOL.CELL PROTEOMICS 11 329 x-ray 2z5d A 1 160 99 2 1 3 156 160 x-ray 2z5d B 1 160 99 2 1 5 157 160 1 2z5d_1 3410 Homo dimer 2z5dB P62256 IID00637 2z5dA P62256 IID00637 2z5dB-2z5dA 2-159 1-1,160-183 12-151 1-11,152-183 8-11,152-155,177-183 135-148,163-177