20210801 20180803 20180328 20210801 IID00640 Ubiquitin-conjugating enzyme E2 E2 E2 ubiquitin-conjugating enzyme E2 UbcH8 Ubiquitin carrier protein E2 Ubiquitin-protein ligase E2 Homo sapiens 201 Q96LR5 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. 0 0 N-acetylserine 2 2 Phosphoserine 11 11 Phosphoserine 15 15 Phosphoserine 18 18 Phosphoserine 19 19 MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT 1 1y6lA 55 201 order 1 2 1y6lB 55 201 order 1 3 1y6lC 55 201 order 1 1 1y6l X-RAY 298K 8.5 22496338 Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANON 2012 MOL CELL PROTEOMICS 11 329 x-ray 1y6l A 55 201 100 0 x-ray 1y6l B 55 201 100 0 x-ray 1y6l C 55 201 100 0 1 1y6l_3 859 Monomer monomer 1y6lC Q96LR5 IID00640 2 1y6l_2 859 Monomer monomer 1y6lB Q96LR5 IID00640 3 1y6l_1 859 Monomer monomer 1y6lA Q96LR5 IID00640 59-201 1-58 1797 PF00179 59->195 1.8e-51 Ubiquitin-conjugating enzyme hmm pfm 4357 2nvuC1 37->200 1e-63 hmm scp 6876 PF00179 59->130 1e-08 Ubiquitin-conjugating enzyme rps pfm 9237 1z2uA1 56->200 4e-77 rps scp