THE NMR SOLUTION STRUCTURE OF THE RELAXIN (RXFP1) RECEPTOR LIPOPROTEIN RECEPTOR CLASS A MODULE AND IDENTIFICATION OF KEY RESIDUES IN THE N-TERMINAL REGION OF THE MODULE THAT MEDIATE RECEPTOR ACTIVATION

20210801 20180803 20180328 20210801 IID00681 Relaxin receptor 1 Leucine-rich repeat-containing G-protein coupled receptor 7 Relaxin family peptide receptor 1 Homo sapiens 757 Q9HBX9 B4DHD1 B4DTV2 Q2M215 Q3KU24 Q3KU25 Q3KU26 Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Cell membrane. SL-0039 unkown 0 0 0 0 RXFP1 RXFP1_HUMAN MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS 1 2jm4A 23 63 order 1 2 2m7pA 28 39 order 2 3 2jm4A 23 25 high_rmsd 1 4 2jm4A 63 63 high_rmsd 1 1 2jm4 NMR 17148455 E.J.HOPKINS,S.LAYFIELD,T.FERRARO,R.A.D.BATHGATE,P.R.GOOLEY THE NMR SOLUTION STRUCTURE OF THE RELAXIN (RXFP1) RECEPTOR LIPOPROTEIN RECEPTOR CLASS A MODULE AND IDENTIFICATION OF KEY RESIDUES IN THE N-TERMINAL REGION OF THE MODULE THAT MEDIATE RECEPTOR ACTIVATION 2007 J.BIOL.CHEM. 282 4172 nmr 2jm4 A 23 63 100 0 1 2jm4 3681 Monomer monomer 2jm4A Q9HBX9 IID00681 2 2m7p NMR R.C.K.KONG,E.J.PETRIE,B.MOHANTY,J.LING,J.C.Y.LEE,P.R.GOOLEY,R.A.D.BATHGATE THE RELAXIN RECEPTOR (RXFP1) UTILISES HYDROPHOBIC MOIETIES ON A SIGNALLING SURFACE OF ITS N-TERMINAL LOW DENSITY LIPOPROTEIN CLASS A MODULE TO MEDIATE RECEPTOR ACTIVATION 2013 J.BIOL.CHEM. nmr 2m7p A 28 39 100 0 1 2m7p_1 2647 Monomer monomer 2m7pA P01130 IID00646 2m7pA Q9HBX9 IID00681 2m7pA-2m7pA 26-43,45-67,93-392,396-398,400-433,437-518,524-566,574-609,614-703 1-25,44-44,68-92,393-395,399-399,434-436,519-523,567-573,610-613,704-757 1-521,529-610,618-697,733-757 522-528,611-617,698-732 522-528,698-732