SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMAN REGULATOR OF G-PROTEIN SIGNALING 10

20210801 20180803 20180328 20210801 IID00693 Regulator of G-protein signaling 10 Homo sapiens 173 O43665 A8K408 B1AMR8 Q6IAZ6 Q96GN0 Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196). Nucleus. SL-0191 unkown 0 0 Phosphoserine 33 33 Phosphoserine 168 168 MQSELCFADIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT 1 2i59A 22 157 order 2 2 2dlrA 23 158 order 1 3 2ihbB 9 23 disorder 3 4 2ihbB 24 102 order 3 5 2ihbB 103 113 disorder 3 6 2ihbB 114 145 order 3 7 2ihbB 146 152 disorder 3 1 2dlr NMR H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMA SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMAN REGULATOR OF G-PROTEIN SIGNALING 10 TO BE PUBLISHED nmr 2dlr A 23 158 100 0 1 2dlr 1702 Monomer monomer 2dlrA O43665 IID00693 2 2i59 NMR 18434541 M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKI STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTION WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS. 2008 PROC.NATL.ACAD.SCI.USA 105 6457 nmr 2i59 A 22 157 100 0 1 2i59 1702 Monomer monomer 2i59A O43665 IID00693 3 2ihb X-RAY 293K 5.5 18434541 M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKI STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTION WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS. 2008 PROC.NATL.ACAD.SCI.USA 105 6457 x-ray 2ihb B 9 152 100 3 9 23 103 113 146 152 1 2ihb_1 2327 Hetero dimer 2ihbA P08754 2ihbB O43665 IID00693 2ihbA-2ihbB 27-145 1-26,146-173 1961 PF00615 33->146 2.2e-37 Regulator of G protein signaling domain hmm pfm 4486 1omwA1 15->154 4.6e-43 hmm scp 7016 PF00615 33->141 1e-05 Regulator of G protein signaling domain rps pfm 9353 1zv4X1 23->150 5e-43 rps scp