20210801 20180803 20180228 20210801 IID00728 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase PYST1 Mitogen-activated protein kinase phosphatase 3 Homo sapiens 381 Q16828 O75109 Q53Y75 Q9BSH6 Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). Nucleus. SL-0191 unkown Cytoplasm. SL-0086 unkown 0 0 0 0 DUSP6 DUS6_HUMAN MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST 1 1hzmA 1 154 order 1 2 1mkpA 205 347 order 2 1 1hzm NMR 11239467 A.FAROOQ,G.CHATURVEDI,S.MUJTABA,O.PLOTNIKOVA,L.ZENG,C.DHALLUIN,R.ASHTON,M.M.ZHOU 2001 MOL.CELL 7 387 nmr 1hzm A 1 154 99 0 1 1hzm 3648 Monomer monomer 1hzmA Q16828 IID00728 2 1mkp X-RAY 6.5 10048930 A.E.STEWART,S.DOWD,S.M.KEYSE,N.Q.MCDONALD 1999 NAT.STRUCT.BIOL. 6 174 x-ray 1mkp A 205 347 99 0 1 1mkp_1 2675 Monomer monomer 1mkpA Q16828 IID00728 16-57,72-74,77-77,81-83,86-89,92-102,113-149,206-349,363-366,368-368,371-374 1-15,58-71,75-76,78-80,84-85,90-91,103-112,150-205,350-362,367-367,369-370,375-381 1-12,17-107,203-352 13-16,108-202,353-381 13-16,113-151,197-202,362-381 115-123,151-187