20250201 IID00804 Ubiquitin-conjugating enzyme E2 A E2 ubiquitin-conjugating enzyme A RAD6 homolog A Ubiquitin carrier protein A Ubiquitin-protein ligase A Homo sapiens 152 P49459 A6NFE9 A6NGR2 A6NMF5 B2R7R9 D3DWI1 Q4TTG1 Q96FX4 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Cytoplasmic vesicle membrane. SL-0089 unkown Cell projection, Dendrite. SL-0283 unkown Cell membrane. SL-0039 unkown Cell junction, Synapse, Postsynaptic cell membrane. SL-0219 unkown 0 0 Phosphoserine; by CDK9 120 120 UBE2A Ubiquitin-conjugating enzyme E2 MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC 1 6cyrA 1 152 order 2 2 6cyoA 1 151 order 1 3 6cyoA 152 152 disorder 1 1 6cyo X-RAY 291K 7 30531907 J.F.DE OLIVEIRA,P.F.V.DO PRADO,S.S.DA COSTA,M.L.SFORCA,C.CANATELI,A.T.RANZANI,M.MASCHIETTO,P.S.L.DE OLIVEIRA,P.A.OTTO,R.E.KLEVIT,A.C.V.KREPISCHI,C.ROSENBERG,K.G.FRANCHINI 2019 NAT. CHEM. BIOL. 15 62 x-ray 6cyo A 1 152 100 1 152 152 1 6cyo 2242 Monomer monomer 6cyoA P49459 IID00804 2 6cyr X-RAY 291K 7 30531907 J.F.DE OLIVEIRA,P.F.V.DO PRADO,S.S.DA COSTA,M.L.SFORCA,C.CANATELI,A.T.RANZANI,M.MASCHIETTO,P.S.L.DE OLIVEIRA,P.A.OTTO,R.E.KLEVIT,A.C.V.KREPISCHI,C.ROSENBERG,K.G.FRANCHINI 2019 NAT. CHEM. BIOL. 15 62 x-ray 6cyr A 1 152 99 0 1 6cyr 2242 Monomer monomer 6cyrA P49459 IID00804 2-151 1-1,152-152 5-152 1-4