20250201 IID00864 Vacuolar-sorting protein SNF8 ELL-associated protein of 30 kDa ESCRT-II complex subunit VPS22 Homo sapiens 258 Q96H20 Q8IXY3 Q9UN50 Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Membrane. SL-0162 unkown 0 0 Omega-N-methylarginine 4 4 SNF8 Vacuolar-sorting protein SNF8 MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP 1 2zmeA 1 33 disorder 1 2 2zmeA 34 250 order 1 3 2zmeA 251 258 disorder 1 4 3cuqA 25 33 disorder 2 5 3cuqA 34 252 order 2 6 3cuqA 253 258 disorder 2 1 2zme X-RAY 18539118 Y.J.IM,J.H.HURLEY INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISM OF THE HUMAN ESCRT-II COMPLEX 2008 DEV.CELL 14 902 x-ray 2zme A 1 258 100 2 1 33 251 258 1 2zme_1 4329 Hetero tetramer 2zmeA Q96H20 IID00864 2zmeD Q9BRG1 IID00869 2zmeC Q9BRG1 IID00869 2zmeB Q86VN1 IID00218 2zmeA-2zmeC 2zmeA-2zmeB 2zmeD-2zmeB 2zmeC-2zmeB 2 3cuq X-RAY 300K 18539118 Y.J.IM,J.H.HURLEY INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISM OF THE HUMAN ESCRT-II COMPLEX 2008 DEV.CELL 14 902 x-ray 3cuq A 25 258 100 2 25 33 253 258 1 3cuq_1 2794 Hetero trimer 3cuqA Q96H20 IID00864 3cuqD Q9BRG1 IID00869 3cuqC Q9BRG1 IID00869 3cuqB Q86VN1 IID00218 3cuqA-3cuqC 3cuqA-3cuqB 3cuqD-3cuqB 3cuqC-3cuqB
Q86VN1-1 VPS36/SNF8/VPS25/VPS25 Integrated structural and functional model of the human ESCRT-II complex Q96FZ7-1 CHMP6/VPS25 Crystal structure of the human VPS25-VPS20 subcomplex 8-80,87-87,92-134,136-240 1-7,81-86,88-91,135-135,241-258 20-248 1-19,249-258 4-19,249-258 8-22