20250201 IID00877 Protein salvador homolog 1 45 kDa WW domain protein Homo sapiens 383 Q9H4B6 A8K4B8 D3DSB6 Q6IA58 Q9H949 Q9HAK9 Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Cytoplasm. SL-0086 unkown 0 0 Phosphoserine 94 94 Phosphoserine 136 136 Phosphothreonine 210 210 SAV1 Protein salvador homolog 1 MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF 1 6ao5B 291 376 order 1 2 6ao5B 377 383 disorder 1 1 6ao5 X-RAY 293K 29063833 S.J.BAE,L.NI,A.OSINSKI,D.R.TOMCHICK,C.A.BRAUTIGAM,X.LUO 2017 ELIFE 6 x-ray 6ao5 B 291 383 100 1 377 383 1 6ao5_1 2605 Hetero dimer 6ao5B Q9H4B6 IID00877 6ao5A Q13188 IID00721 6ao5B-6ao5A

Q9H8S9-1 MOB1A/LATS1 200-229,239-265,292-379 1-199,230-238,266-291,380-383 199-273,304-371 1-198,274-303,372-383 1-44,125-144,154-159,281-303,372-383 275-286