20210801 20180803 20180328 20210801 IID50017 Axin-1 Axis inhibition protein 1 Xenopus laevis 842 Q9YGY0 Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Melanosome. SL-0161 unkown Cytoplasm. SL-0086 unkown Cytoplasm, Cytosol. SL-0091 unkown Nucleus envelope. SL-0178 unkown Nucleus. SL-0191 unkown MSVKGKGFPLDLGGSFTEDAPRPPVPGEEGELITTDQRPFSHTYYSLKNDGIKNETSTATPRRPDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIHLFRTFLQQENCADLLDFWFACSGFRKLEPNDSKVEKRLKLAKAIYKKYVLDSNGIVSRQIKPATKSFIKDCVLRQQIDPAMFDQAQMEIQSMMEDNTYPVFLKSDIYLEYTTIGGESPKNYSDQSSGSGTGKGPSGYLPTLNEDEEWRCDQGGEHERERECIPSSLFSQKLALDSSSHCAGSNRRLSDGREFRPGTWREPVNPYYVNTGYAGAPVTSANDSEQQSMSSDADTMSLTDSSVDGIPPYRLRKHYRREMQESANANGRGPLPHIPRTYHMPKDIHVDPEKFAAELISRLEGVLRDREAEQKLEERLKRVRAEEEGDDGDVSSGPSVISHKLPSGPPMHHFNSRYSETGCVGMQIRDAHEENPESILDEHVQRVMKTPGCQSPGTGRHSPKSRSPDGHLSKTLPGSLGTMQTGHGKHSSKSTAKVDSGNLHHHKHVYHHVHHHGGVKPKEQIDGESTQRVQTNFPWNVESHNYATKSRNYAESMGMAPNPMDSLAYSGKVSMLSKRNAKKADLGKSESASHEMPVVPEDSERHQKILQWIMEGEKEIIRHKKSNHSSSSAKKQPPTELARPLSIERPGAVHPWVSAQLRNVVQPSHPFIQDPTMPPNPAPNPLTQLVSKPGARLEEEEKKAAKMPQKQRLKPQKKNVSAPSQPCDNIVVAYYFCGEPIPYRTMVKGRVVTLGQFKELLTKKGNYRYYFKKVSDEFDCGVVFEEVREDDMILPIYEEKIIGQVEKID 1 1qz7B 435 465 disorder 1 2 1qz7B 466 482 order 1 3 1qz7B 483 504 disorder 1 1 1qz7 X-RAY 298K 5.6 14600025 Y.XING,W.K.CLEMENTS,D.KIMELMAN,W.XU 2003 GENES DEV. 17 2753 x-ray 1qz7 B 435 504 100 2 435 465 483 504 1 1qz7_1 2979 Hetero dimer 1qz7B Q9YGY0 IID50017 1qz7A P35222 IID00039 1qz7B-1qz7A ProS 1 possible 2 466 482 This region interacts with armagillo repeat. 74-219,760-842 1-73,220-364,406-759 365-405 2150 PF00778 762->839 3.8e-34 DIX domain hmm pfm 2151 PF00615 88->210 4e-31 Regulator of G protein signaling domain hmm pfm 2152 PF16646 10->80 1.4e-28 Axin-1 tankyrase binding domain hmm pfm 2153 PF08833 466->496 1.1e-13 Axin beta-catenin binding domain hmm pfm 4606 1dk8A_ 76->215 2.2e-41 hmm scp 4607 1wspA1 761->842 4.2e-31 hmm scp 7177 PF16646 8->80 5e-21 Axin-1 tankyrase binding domain rps pfm 7178 PF00615 87->204 3e-07 Regulator of G protein signaling domain rps pfm 7179 PF16769 351->482 2e-04 MCM3AP domain of GANP rps pfm 7180 PF08833 466->525 2e-06 Axin beta-catenin binding domain rps pfm 7181 PF00778 763->840 7e-18 DIX domain rps pfm 9468 1dk8A 74->219 4e-55 rps scp 9469 1wspA1 760->842 1e-28 rps scp