20210801 20180803 20180328 20210801 IID50017 Axin-1 Axis inhibition protein 1 Xenopus laevis 842 Q9YGY0 Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Melanosome. SL-0161 unkown Cytoplasm. SL-0086 unkown Cytoplasm, Cytosol. SL-0091 unkown Nucleus envelope. SL-0178 unkown Nucleus. SL-0191 unkown axin1 AXIN1_XENLA MSVKGKGFPLDLGGSFTEDAPRPPVPGEEGELITTDQRPFSHTYYSLKNDGIKNETSTATPRRPDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIHLFRTFLQQENCADLLDFWFACSGFRKLEPNDSKVEKRLKLAKAIYKKYVLDSNGIVSRQIKPATKSFIKDCVLRQQIDPAMFDQAQMEIQSMMEDNTYPVFLKSDIYLEYTTIGGESPKNYSDQSSGSGTGKGPSGYLPTLNEDEEWRCDQGGEHERERECIPSSLFSQKLALDSSSHCAGSNRRLSDGREFRPGTWREPVNPYYVNTGYAGAPVTSANDSEQQSMSSDADTMSLTDSSVDGIPPYRLRKHYRREMQESANANGRGPLPHIPRTYHMPKDIHVDPEKFAAELISRLEGVLRDREAEQKLEERLKRVRAEEEGDDGDVSSGPSVISHKLPSGPPMHHFNSRYSETGCVGMQIRDAHEENPESILDEHVQRVMKTPGCQSPGTGRHSPKSRSPDGHLSKTLPGSLGTMQTGHGKHSSKSTAKVDSGNLHHHKHVYHHVHHHGGVKPKEQIDGESTQRVQTNFPWNVESHNYATKSRNYAESMGMAPNPMDSLAYSGKVSMLSKRNAKKADLGKSESASHEMPVVPEDSERHQKILQWIMEGEKEIIRHKKSNHSSSSAKKQPPTELARPLSIERPGAVHPWVSAQLRNVVQPSHPFIQDPTMPPNPAPNPLTQLVSKPGARLEEEEKKAAKMPQKQRLKPQKKNVSAPSQPCDNIVVAYYFCGEPIPYRTMVKGRVVTLGQFKELLTKKGNYRYYFKKVSDEFDCGVVFEEVREDDMILPIYEEKIIGQVEKID 1 1qz7B 435 465 disorder 1 2 1qz7B 466 482 order 1 3 1qz7B 483 504 disorder 1 1 1qz7 X-RAY 298K 5.6 14600025 Y.XING,W.K.CLEMENTS,D.KIMELMAN,W.XU 2003 GENES DEV. 17 2753 x-ray 1qz7 B 435 504 100 2 435 465 483 504 1 1qz7_1 2979 Hetero dimer 1qz7B Q9YGY0 IID50017 1qz7A P35222 IID00039 1qz7B-1qz7A ProS 1 possible 2 466 482 This region interacts with armagillo repeat. 80-128,132-213,352-359,383-419,468-483,636-651,708-709,711-712,714-714,761-842 1-79,129-131,214-351,360-382,420-467,484-635,652-707,710-710,713-713,715-760 80-128,135-216,760-842 1-79,217-759 4-38,59-73,217-223,235-251,284-332,338-345,353-401,406-419,448-457,464-488,499-504,532-535,550-573,585-589,637-655,686-690,704-708,724-730 225-236,537-553,656-668,708-718,731-739