20210801 20180803 20180328 20210801 IID50029 Nuclear protein localization protein 4 homolog Mus musculus 608 P60670 B1ATY4 B1ATY5 The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I. Nucleus. SL-0191 unkown Endomembrane system. SL-0147 unkown Cytoplasm. SL-0086 unkown N-acetylalanine 2 2 N6-acetyllysine 179 179 MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT 1 2pjhA 1 1 disorder 1 2 2pjhA 2 77 order 1 3 2pjhA 78 80 disorder 1 1 2pjh NMR 17491009 R.L.ISAACSON,V.E.PYE,P.SIMPSON,H.H.MEYER,X.ZHANG,P.S.FREEMONT,S.MATTHEWS 2007 J.BIOL.CHEM. 282 21361 nmr 2pjh A 1 80 100 2 1 1 78 80 1 2pjh 3843 Hetero dimer 2pjhB Q01853 IID50030 2pjhA P60670 IID50029 2pjhA-2pjhB 2-77,570-608 1-1,78-133,170-179,552-569 134-169,180-551 2185 PF05021 249->556 4e-130 NPL4 family hmm pfm 2186 PF05020 105->245 2e-65 NPL4 family, putative zinc binding region hmm pfm 2187 PF11543 1->79 1.7e-37 Nuclear pore localisation protein NPL4 hmm pfm 4636 1nj3A_ 581->607 2.2e-12 Ran binding protein zinc finger-like hmm scp 4637 1wf9A1 5->80 4e-11 hmm scp 7201 PF11543 4->79 5e-21 Nuclear pore localisation protein NPL4 rps pfm 7202 PF05020 108->245 5e-51 NPL4 family, putative zinc binding region rps pfm 7203 PF05021 249->556 3e-83 NPL4 family rps pfm 9488 1wf9A1 6->77 2e-04 rps scp 9489 1q5wA1 580->608 2e-11 rps scp