STRUCTURE OF MYOSTATINFOLLISTATIN-LIKE 3: N-TERMINAL DOMAINS OF FOLLISTATIN-TYPE MOLECULES EXHIBIT ALTERNATE MODES OF BINDING.

20210801 20180803 20180425 20210801 IID50111 Growth/differentiation factor 8 Myostatin Mus musculus 376 O08689 Acts specifically as a negative regulator of skeletal muscle growth. Nucleus. SL-0191 unkown 0 0 0 0 MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 1 3sekB 268 376 order 1 2 3hh2A 268 376 order 2 3 3hh2B 268 376 order 2 4 5ji1A 268 317 order 3 5 5ji1A 318 331 disorder 3 6 5ji1A 332 376 order 3 7 5ji1B 268 315 order 3 8 5ji1B 316 332 disorder 3 9 5ji1B 333 376 order 3 1 3sek X-RAY 293K 7.5 22052913 J.N.CASH,E.B.ANGERMAN,C.KATTAMURI,K.NOLAN,H.ZHAO,Y.SIDIS,H.T.KEUTMANN,T.B.THOMPSON STRUCTURE OF MYOSTATINFOLLISTATIN-LIKE 3: N-TERMINAL DOMAINS OF FOLLISTATIN-TYPE MOLECULES EXHIBIT ALTERNATE MODES OF BINDING. 2012 J.BIOL.CHEM. 287 1043 x-ray 3sek B 268 376 100 0 1 3sek_1 3044 Hetero tetramer 3sekB O08689 IID50111 3sekC O95633 IID00192 3sekB-3sekC 3sekB-3sekB 2 3hh2 X-RAY 293K 4.2 19644449 J.N.CASH,C.A.REJON,A.C.MCPHERRON,D.J.BERNARD,T.B.THOMPSON THE STRUCTURE OF MYOSTATIN:FOLLISTATIN 288: INSIGHTS INTO RECEPTOR UTILIZATION AND HEPARIN BINDING 2009 EMBO J. 28 2662 x-ray 3hh2 A 268 376 100 0 x-ray 3hh2 B 268 376 100 0 1 3hh2_1 2264 Hetero tetramer 3hh2D P19883 IID00339 3hh2C P19883 IID00339 3hh2B O08689 IID50111 3hh2A O08689 IID50111 3hh2D-3hh2C 3hh2B-3hh2A 3hh2D-3hh2B 3hh2C-3hh2B 3hh2C-3hh2A 3hh2D-3hh2A 3 5ji1 X-RAY 298K 6 28257634 R.G.WALKER,M.CZEPNIK,E.J.GOEBEL,J.C.MCCOY,A.VUJIC,M.CHO,J.OH,S.AYKUL,K.L.WALTON,G.SCHANG,D.J.BERNARD,A.P.HINCK,C.A.HARRISON,E.MARTINEZ-HACKERT,A.J.WAGERS,R.T.LEE,T.B.THOMPSON STRUCTURAL BASIS FOR POTENCY DIFFERENCES BETWEEN GDF8 AND GDF11. 2017 BMC BIOL. 15 19 x-ray 5ji1 A 268 376 100 1 318 331 x-ray 5ji1 B 268 376 100 1 316 332 1 5ji1_1 2394 Homo dimer 5ji1B O08689 IID50111 5ji1A O08689 IID50111 5ji1B-5ji1A 268-376 1-146,185-203,235-267 147-184,204-234 2373 PF00688 40->239 5.7e-34 TGF-beta propeptide hmm pfm 2374 PF00019 281->375 5.1e-32 Transforming growth factor beta like domain hmm pfm 4780 2tgiA_ 272->375 4.9e-35 hmm scp 7381 PF00688 40->232 9e-15 TGF-beta propeptide rps pfm 7382 PF00019 281->375 9e-14 Transforming growth factor beta like domain rps pfm 9631 5e4gA 269->376 2e-53 rps scp