20210801 20180803 20180228 20210801 IID50125 Gamma-aminobutyric acid receptor subunit gamma-2 GABA(A) receptor subunit gamma-2 Rattus norvegicus 466 P18508 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2561970). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Cytoplasm. SL-0086 unkown 0 0 0 0 Gabrg2 GBRG2_RAT MSSPNTWSTGSTVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 1 2pr9P 400 409 order 1 1 2pr9 X-RAY 291K 6 18305175 J.T.KITTLER,G.CHEN,V.KUKHTINA,A.VAHEDI-FARIDI,Z.GU,V.TRETTER,K.R.SMITH,K.MCAINSH,I.L.ARANCIBIA-CARCAMO,W.SAENGER,V.HAUCKE,Z.YAN,S.J.MOSS 2008 PROC.NATL.ACAD.SCI.USA 105 3616 x-ray 2pr9 P 400 409 100 0 1 2pr9 3849 Hetero dimer 2pr9P P18508 IID50125 2pr9A P84092 IID50122 2pr9A-2pr9P 64-360,436-466 1-63,361-435 59-367,428-466 1-58,368-427 4-35,43-58,377-413 304-320,366-373