20210801 20180803 20180425 20210801 IID50172 Nuclear cap-binding protein complex subunit 1 80 kDa nuclear cap-binding protein Glycolysis regulation protein 3 Protein SUT1 Suppressor of TOP1 protein Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 861 P34160 D6VZU8 Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV. Membrane. SL-0162 unkown Nuclear localization signal 22 30 0 0 STO1 NCBP1_YEAST MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIRTIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMVVNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPMFLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRTKVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNELFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYLPNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEPGESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNSPKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFGKYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLFTGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEYGSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYIIIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAVFRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDIEDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQETKEV 1 3ukyC 1 2 disorder 1 2 3ukyC 3 8 order 1 3 3ukyC 9 22 disorder 1 4 3ukyC 23 30 order 1 1 3uky X-RAY 293K 7 22248489 M.MARFORI,T.G.LONHIENNE,J.K.FORWOOD,B.KOBE 2012 TRAFFIC 13 532 x-ray 3uky C 1 30 100 2 1 2 9 22 1 3uky_1 3152 Hetero dimer 3ukyC P34160 IID50172 3ukyB P52293 IID50009 3ukyC-3ukyB ProS 1 possible 2 3 8 Nuclear Localization Signal (NLS) ProS 2 possible 4 23 30 Nuclear Localization Signal (NLS) 28-336,339-750,756-787,800-861 1-27,337-338,751-755,788-799 30-181,188-289,311-402,409-621,627-671,676-770,802-861 1-29,294-310,622-626,771-801 5-21,26-29,294-310,771-777 750-763,792-806