20210801 20180803 20180425 20210801 IID50172 Nuclear cap-binding protein complex subunit 1 80 kDa nuclear cap-binding protein Glycolysis regulation protein 3 Protein SUT1 Suppressor of TOP1 protein Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 861 P34160 D6VZU8 Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV. Membrane. SL-0162 unkown Nuclear localization signal 22 30 0 0 MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIRTIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMVVNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPMFLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRTKVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNELFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYLPNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEPGESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNSPKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFGKYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLFTGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEYGSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYIIIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAVFRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDIEDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQETKEV 1 3ukyC 1 2 disorder 1 2 3ukyC 3 8 order 1 3 3ukyC 9 22 disorder 1 4 3ukyC 23 30 order 1 1 3uky X-RAY 293K 7 22248489 M.MARFORI,T.G.LONHIENNE,J.K.FORWOOD,B.KOBE 2012 TRAFFIC 13 532 x-ray 3uky C 1 30 100 2 1 2 9 22 1 3uky_1 3152 Hetero dimer 3ukyC P34160 IID50172 3ukyB P52293 IID50009 3ukyC-3ukyB ProS 1 possible 2 3 8 Nuclear Localization Signal (NLS) ProS 2 possible 4 23 30 Nuclear Localization Signal (NLS) 43-842 1-42,843-861 2533 PF09090 582->828 3.5e-56 MIF4G like hmm pfm 2534 PF09088 347->542 3.3e-56 MIF4G like hmm pfm 2535 PF02854 50->251 8.3e-25 MIF4G domain hmm pfm 4906 1h6kA2 356->550 2.4e-66 hmm scp 4907 1h2tC3 580->857 5.2e-57 hmm scp 4908 1h6kA1 48->232 1.8e-12 hmm scp 7511 PF09088 404->542 3e-31 MIF4G like rps pfm 7512 PF09090 582->827 6e-25 MIF4G like rps pfm 9752 1h2vC1 43->270 7e-12 rps scp 9753 1h2vC2 342->548 4e-38 rps scp 9754 1h2vC3 585->844 6e-21 rps scp