20210801 20180803 20180328 20210801 IID50180 BAG family molecular chaperone regulator 1 Bcl-2-associated athanogene 1 Mus musculus 355 Q60739 Q561N1 Q6IS45 Q9D7K6 Co-chaperone for HSP70 and HSC70 chaperone proteins (PubMed:9873016). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity). Secreted. SL-0243 unkown 0 0 0 0 Bag1 BAG1_MOUSE MAGRSAARRPRGDREPLGPRLRAPRPAREPRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAPAGACKPRVKKKVRPRSSQSEKVGSSSRELTRSKKVTRSKNVTGTQVEEVTKIEEATQTEEVTVAEEVTQTDNMAKTEEMVQTEEMETPRLSVIVTHSNERYDLLVTPQQGNSEPVVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEVELKKLKDLEVSAEKIANHLQELNKELSGIQQGFLAKELQAEALCKLDRKVKATIEQFMKILEEIDTMVLPEQFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALAE 1 1i6zA 226 355 order 1 2 2lwpA 137 233 order 2 3 2m8sA 137 233 order 3 4 2lwpA 137 137 high_rmsd 2 5 1i6zA 226 232 high_rmsd 1 6 1i6zA 348 355 high_rmsd 1 1 1i6z NMR 11276257 K.BRIKNAROVA,S.TAKAYAMA,L.BRIVE,M.L.HAVERT,D.A.KNEE,J.VELASCO,S.HOMMA,E.CABEZAS,J.STUART,D.W.HOYT,A.C.SATTERTHWAIT,M.LLINAS,J.C.REED,K.R.ELY STRUCTURAL ANALYSIS OF BAG1 COCHAPERONE AND ITS INTERACTIONS WITH HSC70 HEAT SHOCK PROTEIN. 2001 NAT.STRUCT.BIOL. 8 349 nmr 1i6z A 226 355 100 0 1 1i6z 3654 Monomer monomer 1i6zA Q60739 IID50180 2 2lwp NMR 23277101 H.W.HUANG,C.YU THE NMR SOLUTION STRUCTURE OF THE UBIQUITIN HOMOLOGY DOMAIN OF BCL-2-ASSOCIATED ATHANOGENE 1 (BAG-1-UBH) FROM MUS MUSCULUS. 2013 BIOCHEM.BIOPHYS.RES.COMMUN. 431 86 nmr 2lwp A 137 233 100 0 1 2lwp_1 2607 Monomer monomer 2lwpA Q60739 IID50180 3 2m8s NMR 24628338 K.W.HUNG,H.W.HUANG,C.C.CHO,S.C.CHANG,C.YU NUCLEAR MAGNETIC RESONANCE STRUCTURE OF THE CYTOPLASMIC TAIL OF HEPARIN BINDING EGF-LIKE GROWTH FACTOR (PROHB-EGF-CT) COMPLEXED WITH THE UBIQUITIN HOMOLOGY DOMAIN OF BCL-2-ASSOCIATED ATHANOGENE 1 FROM MUS MUSCULUS (MBAG-1-UBH). 2014 BIOCHEMISTRY 53 1935 nmr 2m8s A 137 233 100 0 1 2m8s_1 2649 Hetero dimer 2m8sA Q60739 IID50180 2m8sB Q99075 IID00579 2m8sA-2m8sB 154-168,179-192,198-208,212-212,214-216,218-229,238-306,312-349,351-351 1-153,169-178,193-197,209-211,213-213,217-217,230-237,307-311,350-350,352-355 151-355 1-150 1-25,52-71,76-88 14-31,69-79,117-134,140-151,235-248