20210801 20180803 20180425 20210801 IID50220 Nuclear receptor subfamily 0 group B member 2 Orphan nuclear receptor SHP Small heterodimer partner Rattus norvegicus 260 P97947 Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). Nucleus envelope. SL-0178 unkown 0 0 Symmetric dimethylarginine; by PRMT5 57 57 Nr0b2 NR0B2_RAT MSSSQSGVCPCQGSASHPTILYTLLSPGPRTRPMAPASRSHCLCQQHRPVRLCAPHRTCREALDVLGKTVAFLRNLPSFCLLPHEDQRRLLEGCWGPLFLLGLAQDTVTFEVAEAPVPSILKKILLEEPNSGAQGAQPPDPPQPSLAAVQWLQHCLESFWSLELGPKEYAYLKGTILFNPDVPGLHASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNISCTLLVDLFFRPVIGDVDITELLEDMLLLR 1 1zh7C 16 26 order 3 2 1zh7D 16 26 order 3 3 1zgyB 115 117 disorder 2 4 1zgyB 118 129 order 2 5 1zgyB 130 131 disorder 2 6 1yp0B 17 28 order 1 1 1yp0 X-RAY 293K 6 15721253 Y.LI,M.CHOI,G.CAVEY,J.DAUGHERTY,K.SUINO,A.KOVACH,N.BINGHAM,S.KLIEWER,H.XU 2005 MOL.CELL 17 491 x-ray 1yp0 B 17 28 100 0 1 1yp0_1 3396 Hetero dimer 1yp0A P33242 IID50074 1yp0B P97947 IID50220 1yp0A-1yp0B 2 1zgy X-RAY 293K 7 15976031 Y.LI,M.CHOI,K.SUINO,A.KOVACH,J.DAUGHERTY,S.A.KLIEWER,H.E.XU 2005 PROC.NATL.ACAD.SCI.USA 102 9505 x-ray 1zgy B 115 131 100 2 115 117 130 131 1 1zgy_1 3424 Hetero dimer 1zgyA P37231 IID00041 1zgyB P97947 IID50220 1zgyA-1zgyB 3 1zh7 X-RAY 293K 7 15976031 Y.LI,M.CHOI,K.SUINO,A.KOVACH,J.DAUGHERTY,S.A.KLIEWER,H.E.XU 2005 PROC.NATL.ACAD.SCI.USA 102 9505 x-ray 1zh7 C 16 26 100 0 x-ray 1zh7 D 16 26 100 0 1 1zh7_1 1668 Hetero dimer 1zh7C P97947 IID50220 1zh7A P45448 IID50211 1zh7C-1zh7A 2 1zh7_2 1668 Hetero dimer 1zh7D P97947 IID50220 1zh7B P45448 IID50211 1zh7D-1zh7B 25-26,42-42,44-116,120-120,124-124,143-207,214-259 1-24,27-41,43-43,117-119,121-123,125-142,208-213,260-260 18-27,43-123,146-260 1-17,28-42,124-141 7-17,28-33,124-128 132-144