20210801 20180803 20180425 20210801 IID50230 Nuclear receptor subfamily 0 group B member 2 Orphan nuclear receptor SHP Small heterodimer partner Mus musculus 260 Q62227 Q53Z53 Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Nucleus. SL-0191 unkown 0 0 Symmetric dimethylarginine; by PRMT5 57 57 MSSGQSGVCPCQGSAGRPTILYALLSPSPRTRPVAPASHSHCLCQQQRPVRLCAPHRTCREALDVLAKTVAFLRNLPSFCHLPHEDQRRLLECCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEASSGTQGAQPSDRPQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR 1 1ymtB 17 26 order 1 2 1ymtB 27 30 disorder 1 3 4nufA 55 115 order 2 4 4nufA 116 142 disorder 2 5 4nufA 143 260 order 2 6 4nufA 53 54 disorder 2 1 1ymt X-RAY 295K 7.5 15707893 I.N.KRYLOVA,E.P.SABLIN,J.MOORE,R.X.XU,G.M.WAITT,J.A.MACKAY,D.JUZUMIENE,J.M.BYNUM,K.MADAUSS,V.MONTANA,L.LEBEDEVA,M.SUZAWA,J.D.WILLIAMS,S.P.WILLIAMS,R.K.GUY,J.W.THORNTON,R.J.FLETTERICK,T.M.WILLSON,H.A.INGRAHAM 2005 CELL(CAMBRIDGE,MASS.) 120 343 x-ray 1ymt B 17 30 100 1 27 30 1 1ymt_1 3389 Hetero dimer 1ymtA P33242 IID50074 1ymtB Q62227 IID50230 1ymtA-1ymtB 2 4nuf X-RAY 298K 9.5 24379397 X.ZHI,X.E.ZHOU,Y.HE,C.ZECHNER,K.M.SUINO-POWELL,S.A.KLIEWER,K.MELCHER,D.J.MANGELSDORF,H.E.XU 2014 PROC.NATL.ACAD.SCI.USA 111 839 x-ray 4nuf A 53 260 96 2 53 54 116 142 1 4nuf_1 2803 Hetero dimer 4nufP Q9DCR4 IID50234 4nufA Q62227 IID50230 4nufA P0AEX9 IID90020 4nufA-4nufA 4nufP-4nufA 54-260 1-53 2702 PF00104 64->240 4e-19 Ligand-binding domain of nuclear hormone receptor hmm pfm 5082 1hg4A_ 18->257 3.5e-51 hmm scp 9914 1pzlA 23->258 2e-33 rps scp