20210801 20180803 20180328 20210801 IID50296 ATP-dependent RNA helicase laf-1 DEAD-box RNA helicase laf-1 Caenorhabditis elegans 708 D0PV95 Q4W5R4 ATP-dependent RNA helicase (PubMed:27546789). Plays a role in RNA remodeling, but is not required for RNA unwinding (PubMed:27546789). Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA (PubMed:26015579, PubMed:27546789). This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing (PubMed:27546789). Promotes liquid-liquid phase separation of P granules, which is a process important for intracellular organization and stress granule assembly (PubMed:26015579). Required for embryonic development (PubMed:19361491, PubMed:26015579). Plays a role in sexual cell fate determination by negatively regulating the translation of the sex determining protein tra-2 (PubMed:9043090, PubMed:9321409, PubMed:26015579). May play a protective role in the response to heat and oxidative stress (PubMed:24844228). Q motif 231 259 DEAD box 397 400 0 0 MESNQSNNGGSGNAALNRGGRYVPPHLRGGDGGAAAAASAGGDDRRGGAGGGGYRRGGGNSGGGGGGGYDRGYNDNRDDRDNRGGSGGYGRDRNYEDRGYNGGGGGGGNRGYNNNRGGGGGGYNRQDRGDGGSSNFSRGGYNNRDEGSDNRGSGRSYNNDRRDNGGDGQNTRWNNLDAPPSRGTSKWENRGARDERIEQELFSGQLSGINFDKYEEIPVEATGDDVPQPISLFSDLSLHEWIEENIKTAGYDRPTPVQKYSIPALQGGRDLMSCAQTGSGKTAAFLVPLVNAILQDGPDAVHRSVTSSGGRKKQYPSALVLSPTRELSLQIFNESRKFAYRTPITSALLYGGRENYKDQIHKLRLGCHILIATPGRLIDVMDQGLIGMEGCRYLVLDEADRMLDMGFEPQIRQIVECNRMPSKEERITAMFSATFPKEIQLLAQDFLKENYVFLAVGRVGSTSENIMQKIVWVEEDEKRSYLMDLLDATGDSSLTLVFVETKRGASDLAYYLNRQNYEVVTIHGDLKQFEREKHLDLFRTGTAPILVATAVAARGLDIPNVKHVINYDLPSDVDEYVHRIGRTGRVGNVGLATSFFNDKNRNIARELMDLIVEANQELPDWLEGMSGDMRSGGGYRGRGGRGNGQRFGGRDHRYQGGSGNGGGGNGGGGGFGGGGQRSGGGGGFQSGGGGGRQQQQQQRAQPQQDWWS 1 1 168 disorder 1 1 CD 26015579 Shana Elbaum-Garfinkle, Younghoon Kim, Krzysztof Szczepaniak, Carlos Chih-Hsiung Chen, Christian R Eckmann, Sua Myong, Clifford P Brangwynne The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics 2015 PNAS 112 7189 219-623 1-218,624-708 2857 PF00270 255->440 2.5e-49 DEAD/DEAH box helicase hmm pfm 2858 PF00271 478->587 6.3e-35 Helicase conserved C-terminal domain hmm pfm 5192 1wp9A2 317->605 1.3e-70 hmm scp 7800 PF14617 294->412 1e-06 U3-containing 90S pre-ribosomal complex subunit rps pfm 7801 PF16203 522->588 5e-05 ERCC3/RAD25/XPB C-terminal helicase rps pfm 10018 2gufA 46->195 6e-05 rps scp 10019 2i4iA3 219->457 e-113 rps scp 10020 5nt7B 466->625 1e-71 rps scp