20210801 20180803 20180228 20210801 IID50299 Transcription elongation factor spt5 Chromatin elongation factor spt5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 990 O13936 Q9US64 The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. 0 0 Phosphoserine 36 36 MDTNSPKSIDKDANSTEVDAAEQDAASVKINSTRASPNGSDLLNDDSEAAKITTNEKQSSPVDSHNESPNDTTINKGEDGNENEVDNVNNNDKKEDEDNVEENEEEADANEEEEEDEEDDEEDEEDEDESGGGRRKRARHDRRNQFLDIEAEVDEDEEELEDEEDEIGREDGFIEEEVGADYVGDDRRHRELDRQRQELQSVDAERLAEEYREKYGRSQTVVGDTSNVPQRLLLPSVNDPNIWAVRCKIGKEKDIVFTIMRKAMDLQYTSSPLEIISAFQRDSLVGYIYVEARKQSHVLDALNGVLNVYTNNMILVPIKEMPDLLKVQKQVVELLPGAYVRIRRGKYAGDLAQVDNLSENGLTARVRIVPRIDYSDGLKRKNSATRPQARLFNESEAFKSNPSKFSKRGPRLFLFNNEEFEDGFLVKDIRISSLITEGVNPTLDEVSKFNPNNEDLDLSSLALSVKGGHAEFQPGDHVEVYVGEQTGVSGVVENVRGSVITMVSSDGLRLDVPSRGLRKRFRHGDYVKVIAGKYKDDTGMVVRISKDEVTFLSDTLMTELTVFSRDLGEASSAQAVNSAYELHDLVQLDVNTVACIFSVDRDTYKVIDQNGGVRTVLASQITMRHSNRRGVATDRNGAEIRIGDKVKEVGGEGKQGTILHIYRAFVFLHNRDIAENNGVFSARSRNVATIAAKGARISADLTKMNPALSNGPALPPVANLKRTIGRDKAIGATVRIRRGPMKGLLGVIKDTTDANARVELHTGNKMVTIPKENLLYTTKTGELISYTEFIERSRGIRPGSISTADGPNVPNWAQGARTPAVANGSRTPAWNTGSRTPAWNSGSKTPAWNSGSRTPAWNSGNKTPAWNAGSRTPAWNSGNKTPAWNVGNKTPAWNSGAKTPAWNAGNKTPSWNNGTKTPAWNANQTPMVANGTNTSWGQTPAYGGFSETNWDTEDNSKPYTAPTPGAWAAPTPGGWDDEEGDSPKYVPPSP 1 4pz8B 827 828 disorder 1 2 4pz8B 829 832 order 1 3 4pz8B 833 844 disorder 1 1 4pz8 X-RAY 291K 6 24939935 S.K.DOAMEKPOR,A.M.SANCHEZ,B.SCHWER,S.SHUMAN,C.D.LIMA 2014 GENES DEV. 28 1323 x-ray 4pz8 B 827 844 94 2 827 828 833 844 1 4pz8_1 2940 Hetero dimer 4pz8B O13936 IID50299 4pz8A P40997 IID50316 4pz8B-4pz8A 239-366,471-567,718-774,799-939 1-238,367-395,687-717,775-798,940-990 396-470,568-686 2864 PF12815 815->867 6.9e-20 Spt5 C-terminal nonapeptide repeat binding Spt4 hmm pfm 2865 PF12815 869->944 7.4e-20 Spt5 C-terminal nonapeptide repeat binding Spt4 hmm pfm 2866 PF03439 241->325 3.7e-32 Early transcription elongation factor of RNA pol II, NGN section hmm pfm 2867 PF00467 524->550 7.1e-11 KOW motif hmm pfm 2868 PF11942 146->235 5.8e-22 Spt5 transcription elongation factor, acidic N-terminal hmm pfm 5196 2do3A1 471->505 1.9e-07 hmm scp 5197 2do3A1 512->570 4.4e-19 hmm scp 5198 1ffkQ_ 300->366 0.00011 hmm scp 5199 1nz9A_ 727->759 4e-05 hmm scp 7810 PF06524 63->129 5e-06 NOA36 protein rps pfm 7811 PF11942 146->235 3e-15 Spt5 transcription elongation factor, acidic N-terminal rps pfm 7812 PF03439 241->325 6e-25 Early transcription elongation factor of RNA pol II, NGN section rps pfm 7813 PF13051 731->775 3e-04 Protein of unknown function (DUF3912) rps pfm 7814 PF12815 818->868 1e-09 Spt5 C-terminal nonapeptide repeat binding Spt4 rps pfm 7815 PF12815 881->926 1e-04 Spt5 C-terminal nonapeptide repeat binding Spt4 rps pfm 10025 1sigA 74->285 3e-05 rps scp 10026 2do3A1 511->571 2e-18 rps scp