THE STRUCTURE OF A BCL-XL/BIM FRAGMENT COMPLEX: IMPLICATIONS FOR BIM FUNCTION

20210801 20180803 20180328 20210801 IID50303 Bcl-2-like protein 11 Bcl2-interacting mediator of cell death Mus musculus 196 O54918 A2ALQ6 O54919 O54920 Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent. BH3 146 160 Phosphoserine; by MAPK 65 65 Phosphoserine 73 73 Phosphoserine 83 83 Bcl2l11 B2L11_MOUSE MAKQPSDVSSECDREGGQLQPAERPPQLRPGAPTSLQTEPQGNPDGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNETYTRRVFANDYREAEDHPQMVILQLLRFIFRLVWRRH 1 1pq1B 139 171 order 1 2 98 169 disorder 2 1 1pq1 X-RAY 298K 4.5 14499110 X.LIU,S.DAI,Y.ZHU,P.MARRACK,J.W.KAPPLER THE STRUCTURE OF A BCL-XL/BIM FRAGMENT COMPLEX: IMPLICATIONS FOR BIM FUNCTION 2003 IMMUNITY 19 341 x-ray 1pq1 B 139 171 100 0 1 1pq1_1 2927 Hetero dimer 1pq1A Q64373 IID50336 1pq1B O54918 IID50303 1pq1A-1pq1B 2 CD 16645638 Hinds MG, Smits C, Fredericks-Short R, Risk JM, Bailey M, Huang DC, Day CL. Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. 2006 Cell Death Differ. 14 128 ProS 1 verified 1 139 171 2 98 169 5-5,62-62,106-106,111-130,141-165,180-196 1-4,6-61,63-105,107-110,131-140,166-179 133-196 1-132 9-20,64-79,91-110,118-132 80-90