STRUCTURE OF A NUMB PTB DOMAIN-PEPTIDE COMPLEX SUGGESTS A BASIS FOR DIVERSE BINDING SPECIFICITY.

20210801 20180803 20180328 20210801 IID50310 Protein numb Drosophila melanogaster 556 P16554 B8A413 B8A419 Q8IPE9 Q961A6 Q9VLB8 Required in determination of cell fate during sensory organ formation in embryos (PubMed:2752427). Restricts developmental potential and promote maturation of intermediary neuronal progenitor (INP) cells probably acting as an antagonist of Notch signaling (PubMed:24550111, PubMed:28899667, PubMed:18342578). 0 0 Phosphothreonine 430 430 Phosphoserine 537 537 Phosphoserine 543 543 numb NUMB_DROME MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL 1 2nmbA 58 63 disorder 1 2 2nmbA 64 205 order 1 3 1ddmA 67 201 order 2 4 2nmbA 64 64 high_rmsd 1 1 2nmb NMR 9846878 S.C.LI,C.ZWAHLEN,S.J.VINCENT,C.J.MCGLADE,L.E.KAY,T.PAWSON,J.D.FORMAN-KAY STRUCTURE OF A NUMB PTB DOMAIN-PEPTIDE COMPLEX SUGGESTS A BASIS FOR DIVERSE BINDING SPECIFICITY. 1998 NAT.STRUCT.BIOL. 5 1075 nmr 2nmb A 58 205 100 1 58 63 1 2nmb 4596 Hetero dimer 2nmbA P16554 IID50310 2 1ddm NMR 10747019 C.ZWAHLEN,S.C.LI,L.E.KAY,T.PAWSON,J.D.FORMAN-KAY MULTIPLE MODES OF PEPTIDE RECOGNITION BY THE PTB DOMAIN OF THE CELL FATE DETERMINANT NUMB. 2000 EMBO J. 19 1505 nmr 1ddm A 67 201 100 0 1 1ddm 4560 Hetero dimer 1ddmA P16554 IID50310 42-42,44-48,67-208,212-226,233-234,268-269,274-275,277-278,306-321,362-376,378-378 1-41,43-43,49-66,209-211,227-232,235-267,270-273,276-276,279-305,322-361,377-377,379-556 68-207 1-67,208-556 10-34,41-61,266-292,298-308,316-319,362-374,501-512,538-543,551-556 43-59,251-262,345-364,391-403,489-500