20210801 20180803 20180425 20210801 IID50314 Pre-mRNA-splicing factor 18 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 251 P33411 D6VUE3 Q02459 Q05724 Component of the U4/U5/U6 snRNP, binding principally to the u5 snRNP. It is not absolutely required for the second step of pre-mRNA splicing at low temperatures but is required at higher temperatures. It may stabilize a particular conformation of the U5 snRNP or orient the U5 snRNP within the U4/U5/U6 snRNP or within the spliceosome. 0 0 0 0 MDLDLASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQESTDEENLSDNQSDDIRTTISKLENRPERIQEAIAQDKTISVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKASLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERTRLWITSIKRLITFEEWYTSNHDSLA 2 1dvkA 198 217 disorder 1 3 1dvkA 218 247 order 1 4 1dvkA 248 251 disorder 1 6 1dvkB 199 217 disorder 1 7 1dvkB 218 247 order 1 8 1dvkB 248 251 disorder 1 9 1dvkA 79 197 order 1 10 1dvkB 79 198 order 1 1 1dvk X-RAY 290K 10737784 J.JIANG,D.S.HOROWITZ,R.M.XU 2000 PROC.NATL.ACAD.SCI.USA 97 3022 x-ray 1dvk A 79 251 99 2 198 217 248 251 x-ray 1dvk B 79 251 99 2 199 217 248 251 1 1dvk_1 2031 Homo dimer 1dvkB P33411 IID50314 1dvkA P33411 IID50314 1dvkB-1dvkA 80-247 1-79,248-251 2909 PF02840 133->244 8.4e-41 Prp18 domain hmm pfm 5218 1dvkA_ 81->246 2.1e-59 hmm scp 7844 PF02840 179->243 3e-19 Prp18 domain rps pfm 10046 1dvkA 80->247 3e-46 rps scp