20210801 20180803 20180228 20210801 IID50320 Cell death activator CIDE-3 Cell death-inducing DFFA-like effector protein C Fat-specific protein FSP27 Mus musculus 239 P56198 Q499X5 Q8BNV7 Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression. 0 0 0 0 Cidec CIDEC_MOUSE MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSKPSRETPRARPCRVSTADRKVRKGIMAHSLEDLLNKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALAKDTMFMVLLKGQKWKPPSEQRKKRAQLALSQKPTKKIDVARVTFDLYKLNPQDFIGCLNVKATLYDTYSLSYDLHCYKAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATEEEQPAKAKPSSLLPACLKMLQ 1 4ikgA 39 40 disorder 1 2 4ikgA 41 118 order 1 1 4ikg X-RAY 291K 23481402 Z.SUN,J.GONG,H.WU,W.XU,L.WU,D.XU,J.GAO,J.W.WU,H.YANG,M.YANG,P.LI 2013 NAT COMMUN 4 1594 x-ray 4ikg A 39 118 97 1 39 40 1 4ikg_1 2330 Monomer monomer 4ikgA P56198 IID50320 41-124,140-217 1-40,125-139,218-239 43-218 1-42,219-239 1-21,29-33,232-239 7-18